达托霉素致嗜酸粒细胞性肺炎的文献分析  

Literature review of eosinophilic pneumonia induced by daptomycin

作　　者：孙宝 白延宁 张媛媛[3] 乔逸 杨志福 王婧雯 文爱东 SUN Bao;BAI Yanning;ZHANG Yuanyuan;QIAO Yi;YANG Zhifu;WANG Jingwen;WEN Aidong(Department of Pharmacy,the Second Affiliated Hospital of Xi’an Medical University,Xi’an Shaanxi 710038,China;Department of Clinical Pharmacy,Yan’an University Affiliated Hospital,Yan’an Shaanxi 716000,China;Department of Pharmacy,the Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang Shaanxi 712030,China;Department of Pharmacy,Xijing Hospital,Air Force Medical University,Xi’an Shaanxi 710032,China)

机构地区：[1]西安医学院第二附属医院药剂科,陕西西安710038 [2]延安大学附属医院临床药学科,陕西延安716000 [3]陕西中医药大学第二附属医院药剂科,陕西咸阳712030 [4]空军军医大学西京医院药剂科,陕西西安710032

出　　处：《中国药物警戒》2022年第7期757-761,共5页Chinese Journal of Pharmacovigilance

基　　金：国家自然科学基金(81573549)。

摘　　要：目的 探讨达托霉素致嗜酸粒细胞性肺炎(eosinophilic pneumonia,EP)的一般规律和特点,为临床合理用药提供参考。方法 以关键词对2004年1月1日至2020年7月31日中国知网、万方数据、维普网、PubMed等数据库进行检索,按照患者一般情况、用药情况、药品不良反应(ADR)发生及转归等进行统计分析。结果 共收集29篇文献,包含了51例达托霉素所致的嗜酸粒细胞性肺炎;男女比例为5.25∶1,老年组发生率最高,为54.91%(28/51);发生时间在1~2周的最多,占27.45%(14/51);临床表现主要为嗜酸粒细胞增多、呼吸困难、发热等。本研究结果表明达托霉素致嗜酸粒细胞性肺炎可能与剂量和年龄相关,而与性别、ADR史和合并用药无关。结论 达托霉素致ADR表现多样,临床医师、临床药师、护士都应该重视达托霉素所致的ADR,提高合理用药,确保临床用药安全。Objective To explore the regularity and characteristics of daptomycin-induced adverse reactions,and to provide reference for clinical rational drug use.Methods Such databases as CNKI,Wanfang,VIP,and PubMed were searched for articles about daptomycin-induced ADR that had been published between January 1,2004 and July 31,2019.Data on conditions of patients,medications,occurrence of ADR and prognosis was statistically analyzed.Results A total of 29 articles involving 51 cases of daptomycin-induced ADR-eosinophilic pneumonia-were included in this study.In these cases,the ratio of males to females was 5.25∶1.Most of the ADR occurred among elderly patients,accounting for 54.91%(28/51).27.45%(14/51) of these ADR occurred within one to two weeks of medication.The main clinical manifestations were eosinophilia,dyspnea and febrile.The risk factors of eosinophilic pneumonia in patients might be related to age and dosage rather than to gender,the ADR history and combination of drugs.Conclusion Daptomycininduced ADR vary,which deserve the attention of clinicians,clinical pharmacists and nurses so as to improve the rational use of drugs,and ensure the safety of medication.

关 键 词：达托霉素 嗜酸粒细胞性肺炎 药品不良反应 文献分析 

分 类 号：R994.11[医药卫生—毒理学]