Effects of reproductive experience on paternal behavior,levels of testosterone,prolactin in serum and dendritic spines in medial prefrontal cortex of mandarin voles  

作　　者：Bo WANG Laifu LI Zhixiong HE Limin WANG Siyi ZHANG Hui QIAO Rui JIA Fadao TAI 

机构地区：[1]Institute of Brain and Behavioral Sciences,College of Life Sciences,Shaanxi Normal University,Xi’an,Shaanxi,China [2]Genetic Engineering Laboratory,College of Biological and Environmental engineering,Xi’an University,Xi’an,Shaanxi,China

出　　处：《Integrative Zoology》2018年第6期711-722,共12页整合动物学（英文版）

基　　金：This research was supported by the National Natural Science Foundation of China(31372213 and 31670421);Fundamental Research Funds for Central University(GK201305009);Xi’an Science Technology Program(CXY1531WL17).

摘　　要：Maternal behaviors and brains change dramatically with pregnancy,parturition and other mothering experiences.However,whether paternal behavior,brain plasticity and levels of relevant hormones also change along with fathering experience and pups’age remains unclear.Using socially monogamous mandarin voles(Micro-tus mandarinus),we found that experienced fathers exhibited more active paternal behaviors,such as licking,retrievals and nest building,but less paternal care,such as huddling,than new fathers.The high levels of licking and nest building appeared in the earlier days of their mate’s lactation.Experienced fathers retrieved 9–13-day-old pups more frequently.However,these paternal behaviors did not show significant changes with age of pups in new fathers.In addition,experienced fathers had dramatically higher prolactin levels than new fathers but had similar concentrations of testosterone to new fathers.New fathers had lower levels of testosterone but higher levels of prolactin than new paired males.The fathers had higher prolactin levels in the earlier days of their mate’s lactation.The new and experienced fathers had similar dendritic length and spine density on pyramidal neurons in the medial prefrontal cortex but displayed higher levels than new paired males.Taken together,these results indicate that reduction of testosterone levels and increase of prolactin levels may be associated with initiation of paternal care.Fathering experience significantly affects levels of parental care and paternal behaviors toward different aged pups,and brain plasticity can also be enhanced by transition to fatherhood.

关 键 词：dendritic spines paternal behavior PROLACTIN reproductive experience TESTOSTERONE 

分 类 号：D67[政治法律—政治学]