类风湿关节炎并发OP患者免疫球蛋白、淋巴细胞亚群、IL-27及IL-6水平的研究  

Effects of immunoglobulin,lymphocyte subsets,IL-27 and IL-6 levels in patients with rheumatoid arthritis complicated with OP

作　　者：李兰亚[1] 伍广 屠涛 Li Lanya;Wu Guang;Tu Tao(Department of Laboratory,Muyang Hospital of Traditional Chinese Medicine,Suqian 223600,China)

机构地区：[1]沭阳县中医院检验科,江苏宿迁223600

出　　处：《国际免疫学杂志》2022年第2期158-163,共6页International Journal of Immunology

摘　　要：目的探讨免疫球蛋白、淋巴细胞亚群、白细胞介素(interleukin,IL)27和IL-6在类风湿关节炎(rheumatoid arthritis,RA)合并骨质疏松(osteoporosis,OP)患者中的表达及临床意义。方法选取2018年1月至2020年12月沭阳县中医院收治的268例RA患者为研究对象,测定所有患者的骨密度(bone mineral density,BMD)水平,根据测定结果以及患者是否存在脆性骨折史判定患者是否合并OP,其中未合并OP的195例患者纳入研究组1,合并OP的73例患者纳入研究组2,收集两组的临床资料;另外选取同时期在本院进行健康体检的健康人100例纳入对照组,测定研究组和对照组患者免疫球蛋白、淋巴细胞亚群、IL-27和IL-6水平,分析RA合并OP患者与上述指标间的相关性。结果研究组1的性别、年龄、RA病程、关节肿胀数(swollen joint count,SJC)、关节压痛数(joint tenderness,TJC)、红细胞沉降率(erythrocyte sedimentation rate,ESR)、28处关节疾病活动度评估(disease activity score-28,DAS-28)与研究组2对比差异具有统计学意义[(男81例,女114例)比(男20例,女53例),(52.49±4.86)岁比(59.51±4.90)岁,(5.41±1.23)年比(7.65±1.52)年,(4.26±1.09)个比(5.63±1.14)个,(8.21±2.24)个比(9.02±2.35)个,(51.69±4.82)mm/h比(65.23±5.07)mm/h,35/84/76比5/12/56,χ2/t/U值分别为4.52、23.73、17.85、9.05、5.15、23.90、5.22,P值均<0.05]。研究组1和研究组2的免疫球蛋白(immunoglobulin,Ig)A、IgG和IgM水平均高于对照组[g/L:(4.56±1.02)、(5.63±1.15)比(2.71±0.36),(16.63±2.34)、(25.66±3.82)比(13.05±2.03),(3.35±0.36)、(3.91±0.42)比(2.35±0.33),F值分别为232.50、502.57、425.60,P值均<0.05]。研究组1和研究组2与对照组患者CD8^(+)水平差异无统计学意义[%:(28.37±3.45)、(28.23±3.52)比(28.96±3.42),F=1.25,P>0.05];但研究组1和研究组2的CD4^(+)及CD4^(+)/CD8^(+)水平均低于对照组[%:(40.52±5.41)、(34.28±4.26)比(43.85±3.89);(1.42±0.33)、(1.28±0.26)比(1.51±0.35),F值分别为84.12、10.71,P�Objective To investigate the expression level and clinical significance of immunoglobulin,lymphocyte subsets,interleukin(IL)-27 and IL-6 in patients with rheumatoid arthritis(RA)complicated with osteoporosis(OR).Methods A total of 268 RA patients admitted from January 2018 to December 2020 were selected as the study subjects from Shuyang Hospital of Traditional Chinese Medicine.The bone mineral density(BMD)level of all patients was measured,and the patients with OP were determined based on the results and the history of brittle fracture.Including unincorporated OP 195 patients were regarded as group 1,merge the OP 73 patients as group 2,in addition to select the physical examination of healthy people 100 cases in control group the same period in our hospital.Immuneglobulin(Ig),lymphocyte subgroup,and the levels of IL-6,IL-27 of he group and the control group patients were detected.The correlation between RA patients with OP and the above indicators was analyzed.Results Age,AR course,swollen joint count(SJC),joint tenderness(TJC),erythrocyte sedimentation rate(ESR),disease activity score of 28 joints(DAS-28)showed statistically significant differences betwent study group and control group[(81 males,114 females)vs(20 males,53 females),(52.49±4.86)vs(59.51±4.90),(5.41±1.23)vs(7.65±1.52),(4.26±1.09)vs(5.63±1.14),(8.21±2.24)vs(9.02±2.35),(51.69±4.82)vs(65.23±5.07),35/84/76 vs 5/12/56,χ2/t/U values were 4.52,23.73,17.85,9.05,5.15,23.90,5.22,respectively,all P values<0.05).The levels of IgA,IgG and IgM in study group 1 and study group 2 were higher than those in control group[g/L:(4.56±1.02),(5.63±1.15)vs(2.71±0.36),(16.63±2.34),(25.66±3.82)vs(13.05±2.03),(3.35±0.36),(3.91±0.42)to(2.35±0.33),F values were 232.50,502.57,425.60,all P values<0.05).There was no significant difference in CD8^(+)levels between study group 1,study group 2 and control group[%:(28.37±3.45),(28.23±3.52)vs(28.96±3.42),F=1.25,P>0.05).However,the levels of CD4^(+)and CD4^(+)/CD8^(+)in study group 1 and study group 2 were lower

关 键 词：类风湿关节炎 骨质疏松 免疫球蛋白 淋巴细胞亚群 白细胞介素27 白细胞介素6 

分 类 号：R593.22[医药卫生—内科学] R580[医药卫生—临床医学]