南海软珊瑚共附生真菌Aspergillus sp.EGF15-0-3中色酮、蒽醌及其二聚体类化合物  

Xanthones,anthraquinone and their dimers from soft coral-associated symbiotic and epiphytic fungus Aspergillus sp.EGF15-0-3

作　　者：黎咏怡 蔡金旋 方越 李家欣 钟小倩 韦霞 刘炳新[1] 张翠仙[1] LI Yongyi;CAI Jinxuan;FANG Yue;LI Jiaxin;ZHONG Xiaoqian;WEI Xia;LIU Bingxin;ZHANG Cuixian(School of Pharmaceutical Sciences,Guangzhou University of Chinese Medicine,Guangzhou 510006,China)

机构地区：[1]广州中医药大学中药学院,广东广州510006

出　　处：《中山大学学报（自然科学版）（中英文）》2022年第4期70-78,共9页Acta Scientiarum Naturalium Universitatis Sunyatseni

基　　金：广东省自然资源厅专项资金(粤自然资合[2020]039,[2021]048);广东省大学生创新创业项目(S202010572122);广东省科技计划项目(2017A020217008,2015A020216017);广州中医药大学薪火计划重点项目(XH20170110);NSFC(81741160);广东省自然科学基金(2014A030313411)。

摘　　要：在持续挖掘南海软珊瑚共附生真菌Aspergillus sp.EGF15-0-3结构新颖化合物的过程中,经多种柱色谱技术从其PDA培养基的乙酸乙酯部位分离得到9个色酮、蒽醌及其二聚体类化合物,通过波谱学方法:NMR、MS和ORD等并结合文献数据比对鉴定其结构分别为:eurorubrin(1)、anhydro flavomannin-quinone-6,6′-dimethyl ether(2)、asperflavin(3)、8-O-methyl ether-asperflavin(4)、emodin(5)、1-O-methyl emodin(6)、physcion(7)、rubrocristin(8)和3-O-(α-D-ribofuranosyl)-questin(9)。其中1由两分子3通过亚甲基桥链接而成,而2则是由torosachrysone与大黄素组成的杂合二聚体类化合物。化合物2为首次得到的天然产物,化合物1、2、4和9皆首次从Aspergillus属得到。In order to research the novel compounds from the soft coral-associated symbiotic and epiphytic fungus Aspergillus sp.EGF15-0-3,the column chroma tography with SiO2,ODS,Sephdex LH-20,RP-HPLC,and etc.were carried out,and two xanthones,five anthraquinones and two dimers were isolated from PDA medium.According to the(HR)ESI-MS,1D and 2D NMR,ORD,UV,and comparison with the literatures,their structures were determined as eurorubrin(1),anhydro flavomannin-quinone-6,6′-dimethyl ether(2),asperflavin(3),8-O-methyl ether-asperflavin(4),emodin(5),1-O-methyl emodin(6),physcion(7),rubrocristin(8),and 3-O-(α-D-ribofuranosyl)-questin(9).1 consisted of two asperflavins,and 2 was a heterodimer of torosachrysone and emodin,and was a firstly natural product.1,2,4 and 9 were obtained from genus of Aspergillus for the first time.

关 键 词：Aspergillus sp.EGF15-0-3 色酮 蒽醌 (杂合)二聚体 

分 类 号：R931.77[医药卫生—生药学] O629.7[医药卫生—药学]