探讨阿尔茨海默病/血管性痴呆异病同治的炎症机制  

Discussion on the inflammatory mechanism of co-treatment of Alzheime’s disease/vascular dementia

作　　者：任北大 王庆国 程发峰 王雪茜 高颖[1,2] REN Bei-da;WANG Qing-guo;CHENG Fa-feng;WANG Xue-qian;GAO Ying(Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China;Institute for Brain Disorders,Beijing University of Chinese Medicine,Beijing 100700,China;College of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]北京中医药大学东直门医院,北京100700 [2]北京中医药大学中医脑病研究院,北京100700 [3]北京中医药大学中医学院,北京100029

出　　处：《中华中医药杂志》2022年第6期3116-3122,共7页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：中医药传承与创新“百千万”人才工程(岐黄工程)——国家中医药领军人才支持计划(No.国中医药人教发[2018]12号);国家重点研发计划项目(No.2018YFC1705000,No.2018YFC1705001)。

摘　　要：阿尔茨海默病(AD)和血管性痴呆(VD)在痴呆发病种类中占比高,是最为常见的两类老年痴呆,具有高发病率、高致残率、高病死率及低龄化趋势的特点,严重影响人们的健康和生命,而目前关于两病的发病机制仍不明确。炎症反应在两病发病机制中均有重要作用,参与疾病发生、发展及预后的全过程。探讨两病在炎症反应中的共同发病机制,明确炎症反应发挥作用的靶点,为从炎症反应角度思考AD和VD共同发病机制提供新的思路,也为动物实验和临床诊治提供有益的探索,同时也是从微观角度对中医异病同治模式在西医机制探索方面进行积极尝试,具有理论探讨和实践指导的双重意义。Alzheimer’s disease(AD)and vascular dementia(VD)account for the highest proportion in the incidence of dementia and they are the top two types of senile dementia.They have the characteristics of high incidence,high disability rate,high mortality rate and low aging trend,seriously affecting people’s health and life.However,the pathogenesis of these two diseases are still unclear at present.Inflammatory may plays an important role in the pathogenesis and whole process of occurrence,development and prognosis of both diseases.By discussing these two disease in common pathogenesis of inflammation and relevant function targets,we provided new thoughts in the perspective of the inflammatory response the pathogenesis of AD and VD and guidance for animal experiment and clinical diagnosis and treatment provided the beneficial exploration.At the same time,it is also an active attempt to explore the mechanism of Western medicine in the mode of treating different diseases together from a micro perspective.It has both theory and practice guidance significance.

关 键 词：阿尔茨海默病 血管性痴呆 异病同治 炎症反应 机制 小胶质细胞 星形胶质细胞 炎症因子 

分 类 号：R749.1[医药卫生—神经病学与精神病学]