非小细胞肺癌中医证候的舌脉诊参数特征  

Characteristics of tongue and pulse diagnosis parameters of traditional Chinese medicine syndrome in non-small cell lung cancer

作　　者：石玉琳 刘嘉懿 李军 毕紫娟 李加才 胡晓娟 龚亚斌[3] 刘苓霜[4] 许家佗[1] SHI Yu-lin;LIU Jia-yi;LI Jun;BI Zi-juan;LI Jia-cai;HU Xiao-juan;GONG Ya-bin;LIU Ling-shuang;XU Jia-tuo(Basic Medical College,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Shanghai Innovation Center of TCM Health Service,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China;Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)

机构地区：[1]上海中医药大学基础医学院,上海201203 [2]上海中医药大学上海中医健康服务协同创新中心,上海201203 [3]上海中医药大学附属岳阳中西医结合医院,上海200437 [4]上海中医药大学附属龙华医院,上海200032

出　　处：《中华中医药杂志》2022年第6期3395-3400,共6页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家重点研发计划中医药现代化研究重点专项(No.2017YFC1703301);国家自然科学基金项目(No.81873235,No.81973750,No.81904094);上海市科委启明星培育项目(No.22YF1448900);上海市教委预算内项目(No.2021LK029)。

摘　　要：目的:研究非小细胞肺癌不同中医证候间舌脉诊参数变化特点及规律。方法:使用自主研发的TFDA-1型数字舌面诊仪及PDA-1型数字脉诊仪,采集384例非小细胞肺癌患者舌脉诊数据,分析不同证型舌脉诊参数特征。结果:与气虚证比较,阴虚证TB-L、TC-b升高(P<0.05);阴阳两虚证TB-a、TB-Cr、TC-a、TC-S、TC-Cr升高(P<0.01,P<0.05),TB-MEAN、TC-ENT降低(P<0.05);气滞血瘀证TC-b、TC-S升高(P<0.05)。与阴虚证比较,气阴两虚证和痰湿凝结证TC-b降低(P<0.05)。与气阴两虚证比较,气滞血瘀证TC-b显著升高(P<0.01)。与气滞血瘀证比较,痰湿凝结证TC-b、TC-S降低(P<0.01,P<0.05)。TC-S分布趋势:气虚证<痰湿凝结证<气滞血瘀证<阴阳两虚证,TC-b分布趋势:痰湿凝结证<气阴两虚证<气虚证<阴虚证<气滞血瘀证。与气虚证比较,阴阳两虚证h_(1)、h_(4)、h_(1)/t_(1)升高(P<0.05,P<0.01);气阴两虚证t、t_(4)、t_(5)降低(P<0.05,P<0.01);痰湿凝结证t、h_(4)/h_(1)降低(P<0.05)。与阴虚证比较,痰湿凝结证h_(4)/h_(1)降低(P<0.01)。与气阴两虚证比较,阴阳两虚证t_(4)、h3、h_(4)、t_(4)/t_(5)升高(P<0.05,P<0.01),气滞血瘀证t_(4)升高(P<0.01)。与阴阳两虚证比较,痰湿凝结证h_(4)、h_(4)/h_(1)降低(P<0.01)。t_(4)分布趋势:气阴两虚证<气虚证<阴阳两虚证<气滞血瘀证,h_(4)/h_(1)分布趋势:痰湿凝结证<气虚证<阴阳两虚证<阴虚证。结论:非小细胞肺癌不同中医证候的舌脉诊参数有一定的分布规律,可为非小细胞肺癌临床证候诊断提供依据。Objective:To study the characteristics and distribution of tongue and pulse diagnosis parameters in different syndromes of non-small cell lung cancer(NSCLC).Methods:Tongue and pulse diagnosis data of 384 patients with NSCLC were collected using the self-developed TFDA-1 digital tongue and surface diagnosis instrument and PDA-1 digital pulse diagnosis instrument,and the characteristics of tongue and pulse diagnosis parameters of different syndromes were analyzed.Results:Compared with qi deficiency syndrome,TB-L and TC-b increased in yin deficiency syndrome(P<0.05),TB-a,TB-Cr,TC-a,TC-S,TC-Cr increased(P<0.01,P<0.05),TB-MEAN and TC-ENT decreased in yin and yang deficiency syndrome(P<0.05),TC-b and TC-S increased in qi stagnation and blood stasis syndrome(P<0.05).Compared with yin deficiency syndrome,TC-b decreased in qi and yin deficiency syndrome and phlegm and dampness condensation syndrome(P<0.05).Compared with qi and yin deficiency syndrome,TC-b was significantly increased in qi stagnation and blood stasis syndrome(P<0.01).Compared with qi stagnation and blood stasis syndrome,TC-b and TC-S in phlegm and dampness condensation syndrome decreased(P<0.01,P<0.05).TC-S had the following distribution order:qi deficiency syndrome<phlegm and dampness condensation syndrome<qi stagnation and blood stasis syndrome<yin and yang deficiency syndrome,TC-b had the following distribution order:phlegm and dampness condensation syndrome<qi and yin deficiency syndrome<qi deficiency syndrome<yin deficiency syndrome<qi stagnation and blood stasis syndrome.Compared with qi deficiency syndrome,h_(1),h_(4),and h_(1)/t_(1) increased in yin and yang deficiency syndrome(P<0.05,P<0.01),t,t_(4),and t_(5) decreased in qi and yin deficiency syndrome(P<0.05,P<0.01),t and h_(4)/h_(1) decreased in phlegm and dampness condensation syndrome(P<0.05).Compared with yin deficiency syndrome,h_(4)/h_(1) decreased in phlegm and dampness condensation syndrome(P<0.01).Compared with qi and yin deficiency syndrome,t_(4),h3,h_(4),and t_(4)/t_(5) increased in yi

关 键 词：非小细胞肺癌 中医证候 舌诊 脉诊 诊断 

分 类 号：R273[医药卫生—中西医结合]