原发性高血压患者血浆致动脉硬化指数与左心室质量指数的相关性研究  

Correlation between atherogenic index of plasma and left ventricular mass index in patients with essential hypertension

作　　者：沈飞燕 张政 SHEN Feiyan;ZHANG Zheng(Department of Cardiology,Zhongshan Hospital Affiliated to Fudan University,Shanghai 201700,China)

机构地区：[1]复旦大学附属中山医院青浦分院心内科,201700

出　　处：《心肺血管病杂志》2022年第7期749-753,共5页Journal of Cardiovascular and Pulmonary Diseases

基　　金：上海市青浦区科技发展基金项目(QKY2021-12)。

摘　　要：目的:分析血浆致动脉粥样硬化指数(AIP)与原发性高血压患者的左心室质量指数的相关性。方法:本研究为回顾性研究,连续选取2020年1月至2021年12月,复旦大学附属中山医院青浦分院心内科门诊及病房的高血压患者694例,男性403例,女性291例,年龄18~80岁。根据AIP指数进行两等分,分为AIP低组和AIP高组,比较两组间一般临床资料和超声心动图参数的差异,并利用多因素Logistic回归模型分析AIP与左心室肥厚的相关性。结果:AIP高组男性比例更高,BMI更大,年龄更小,吸烟率更高且差异均有统计学意义(P<0.05);AIP高组的24h平均收缩压、24h平均舒张压、血肌酐、TC、TG、血UA及FBG较低组均显著升高(P<0.05);AIP高组的HDL-C较低组显著降低(P<0.001)。AIP高组室间隔厚度(IVST)、左心室后壁厚度(LVPW)、LVEDD、LVESD均显著高于AIP低组(P<0.05);AIP高组左心室质量指数(LVMI)显著高于低组[(100.1±24.3)vs.(95.9±25.0),P=0.024]。在调整了性别、年龄、高血压病程、吸烟史、BMI、24h平均收缩压和糖尿病史的多因素Logistic回归模型中,AIP高组有更高的左心室肥厚风险(OR=1.68,95%CI:1.04~2.71,P=0.03)。结论:在原发性高血压患者中,AIP升高与左心室肥厚风险增加显著相关。Objective:To analyze the correlation between atherogenic index of plasma(AIP)and left ventricular mass index in patients with essential hypertension.Methods:This study was a retrospective study.694 hypertension patients,403 males and 291 females,aged from 18 to 80 years old,were selected from the outpatient Department and Ward of Cardiology Department,Qingpu Branch,Zhongshan Hospital affiliated to Fudan University from January 2020 to December 2021.According to the value of AIP,two groups were divided into low AIP group and high AIP group.The differences of general clinical data and echocardiographic parameters between the two groups were compared,and the independent correlation between AIP and left ventricular hypertrophy was analyzed by multivariate Logistic regression analysis.Results:The proportion of male,BMI,age and smoking rate were higher in the group with higher AIP(P<0.05).24h average systolic blood pressure,24h average diastolic blood pressure,serum creatinine,total cholesterol,triglyceride,serum uric acid and fasting blood glucose in high AIP group were significantly increased(P<0.05);HDL-C was significantly lower in the high AIP group than in the low AIP group(P<0.001).IVST,LVPW,LVD and LVS in high AIP group were significantly higher than those in low AIP group(P<0.05).LVMI in high AIP group was significantly higher than that in low AIP group[(100.1±24.3)vs.(95.9±25.0),P=0.024].In multivariate Logistic regression model fully adjusted for gender,age,duration of hypertension,smoking history,BMI,24h average systolic blood pressure,history of coronary heart disease,and history of diabetes,high AIP group had a higher risk of left ventricular hypertrophy[OR(95%CI):1.68(1.04-2.71),P=0.03].Conclusions:Our study showed that higher AIP was significantly associated with an increased risk of left ventricular hypertrophy in patients with essential hypertension.

关 键 词：血浆致动脉硬化指数 左心室肥厚 左心室质量指数 原发性高血压 

分 类 号：R54[医药卫生—心血管疾病]