全球药用植物干细胞库建设策略及展望  

Construction strategies and prospect of the Global Medicinal Plant Stem Cell Bank

作　　者：向丽[1] 高冉冉 王梦月 肖乐义 刘元柱 陈士林[1] XIANG Li;GAO Ran-ran;WANG Meng-yue;XIAO Le-yi;LIU Yuan-zhu;CHEN Shi-lin(Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China;Medicinal Plant Stem Cell Joint Research and Development Laboratory,Qingdao Yanding Cell Biotechnology Co.,Ltd.,Qingdao 266699,China)

机构地区：[1]中国中医科学院中药研究所,北京100700 [2]青岛言鼎细胞生物科技有限公司药用植物干细胞联合研发实验室,山东青岛266699

出　　处：《中国中药杂志》2022年第11期2841-2851,共11页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金联合基金项目(U1812403-1);国家自然科学基金重大项目(81891010,81891013)。

摘　　要：药用植物干细胞是从药用植物分生组织及维管形成层中分离,一定条件下可产生具有防治疾病、增进机体身心机能活性成分的一类植物干细胞,来源于广义范畴的药用植物,如民族药、民间药、保健食品原料、蔬菜水果以及潜在的药用植物。目前,药用植物干细胞的分离、鉴定、保存及培养技术已日趋成熟,分化、发育、次生产物调控机制研究已较为深入,在药品、保健食品、食品、医美产品等方面应用前景广阔。作为战略资源,首次提出构建国家级乃至世界级的“全球药用植物干细胞库”,对全球万种药用植物资源进行分类逐级保存,依托国家中医药国际化战略走向世界。“全球药用植物干细胞库”应具有安全性、环保性、先进性和实用性,包括植株母库、干细胞株库、组分资源库、基因实体库、数据库以及资源共享体系等,将基因资源、数据资源均纳入保护和利用范畴。“全球药用植物干细胞库”将开启药用植物资源保护与再生新战略,为天然产物新药创制提供新资源,并提供万种药用植物干细胞资源技术共享平台,作为资源宝库、创新技术源头及交流合作中心,将成为全球药用植物干细胞产业的核心驱动力。Medicinal plant stem cells are separated from the meristem and vascular cambium of medicinal plants, which can produce active components for preventing and treating diseases and improving body physical functions under certain conditions. Medicinal plant stem cells come from a broad category of medicinal plants, including ethnic medicinal plants, folk medicinal plants, original plants of health products, vegetables, fruits, and other potential medicinal plants. At present, the techniques for the isolation, identification, preservation and culture of medicinal plant stem cells have become increasingly mature, and the mechanism of stem cell differentiation, growth and regulation of secondary metabolites has been studied in depth. Medicinal plant stem cells have a broad application prospect in medicine, health food, food and medical beauty products. As a strategic resource, the construction of the "Global Medicinal Plant Stem Cell Bank" was first proposed to preserve various kinds of medicinal plant resources in the world, and it will go global relying on the internationalization strategy of traditional Chinese medicine. The bank should follow safety, environmental protection, advanced and practical design principles. The main construction contents include the original plant bank, stem cell bank, component resource bank, gene bank, database and resource sharing system, with genetic and data resources incorporated into the scope of protection and utilization. The bank will establish a new strategy for medicinal plant resources protection and regeneration, and provide a new resource for natural products drug discovery and a technology sharing platform for various medicinal plant stem cells. As a resource treasury, a source of innovative technologies and a center of cooperation, it will become the core driving force of the global medicinal plant stem cell industry.

关 键 词：药用植物干细胞 植物干细胞 全球植物干细胞库 建设策略 

分 类 号：R282.71[医药卫生—中药学]