抗乙型肝炎病毒药物的活性及其机制的研究进展  

Research progress on activities and mechanisms of anti-hepatitis B virus drugs

作　　者：林雅丽 袁文钦 陈林林 樊启猛 钟瑞 郁晶怡 陈乃宏[2] 刘应蛟 LIN Ya-li;YUAN Wen-qin;CHEN Lin-lin;FAN Qi-meng;ZHONG Rui;YU Jing-yi;CHEN Nai-hong;LIU Ying-jiao(School of Pharmacy,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China;Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)

机构地区：[1]江西中医药大学药学院,江西南昌330004 [2]中国医学科学院北京协和医学院药物研究所,北京100050

出　　处：《中国中药杂志》2022年第11期2880-2889,共10页China Journal of Chinese Materia Medica

基　　金：博士启动资金项目(5152100127);江西省中医药管理局科技计划项目(2021A333);江西中医药大学校级科技创新团队发展计划项目;湖南省自然科学基金项目(2019JJ50435);2021年中央财政国家重点野生动植物保护资金项目(2130211)。

摘　　要：乙型肝炎病毒(hepatitis B virus, HBV)是引起乙型肝炎的病原体,具有传染性强、发病率高和流行范围广等特点,严重威胁着人类的健康,影响人们的生活质量。抗HBV西药主要有核苷(酸)和干扰素2类,其中核苷(酸)类使用较多,易产生耐药现象,治疗效果并不突出;干扰素容易引起肝损伤等严重不良反应;抗HBV中药主要有中药单味药(如茵陈、青蒿、丹参等)和中药复方(如茵陈蒿汤、小柴胡汤、调肝化纤丸等),存在化学成分及作用靶点的不明确性;联合用药优于单独使用,能够改善耐药性、取长补短、减少不良反应和延长作用时间等。该研究综述了西药、中药以及联合用药抗HBV活性及其机制,以期为抗HBV新药物的开发及深入研究提供参考。Hepatitis B virus(HBV) is the pathogen causing hepatitis B, which is characterized by strong infectivity, high incidence, and widespread prevalence and has seriously threatened human health and affected their quality of life. Anti-HBV drugs in western medicine mainly include nucleosides(nucleic acids) and interferons, among which nucleosides(nucleic acids) are used more often. Due to the easy development of drug resistance, their therapeutic effects are not remarkable. Interferons can easily cause serious adverse reactions such as liver injury. Anti-HBV drugs in traditional Chinese medicine mainly include single Chinese herbs(Artemisiae Scopariae Herba, Artemisiae Annuae Herba, Salviae Miltiorrhizae Radix et Rhizoma, etc.) and Chinese herbal compounds(Yinchenhao Decoction, Xiaochaihu Decoction, Tiaogan Huaxian Pills, etc.), whose chemical compositions and action targets have not been fully identified. The combined medication is better than single medication, in that the former can improve drug resistance, make up each other′s deficiencies, reduce adverse reactions, and prolong the action time. This study reviewed the anti-HBV activities and mechanisms of western drugs, Chinese herbs, and combined medications, in order to provide reference for the development and research of new anti-HBV drugs.

关 键 词：乙型肝炎病毒 中药 西药 活性 机制 

分 类 号：R285[医药卫生—中药学]