小胶质细胞参与全身麻醉对发育期大脑影响的研究进展  

Research advances in microglia cells involved in general anesthesia on developing brain

作　　者：侯琪 郑晖 Hou Qi;Zheng Hui(Department of Anesthesiology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China)

机构地区：[1]国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院麻醉科,北京100021

出　　处：《国际麻醉学与复苏杂志》2022年第5期550-554,共5页International Journal of Anesthesiology and Resuscitation

基　　金：国家自然科学基金面上项目(81970994)。

摘　　要：研究表明,生命早期使用麻醉药可能造成远期学习和记忆功能损伤。全身麻醉造成的认知功能障碍可能与小胶质细胞有关。文章通过回顾小胶质细胞的发育与激活过程,结合发育期大脑特点,对小胶质细胞参与全身麻醉药物影响发育期脑功能进行总结。探究发育中大脑小胶质细胞的调节及与特定麻醉药的相互作用,对揭示全身麻醉所致发育期神经毒性有重要意义。Recent studies have shown that the use of anesthetics in early life may cause long‑term learning and memory impair‑ment.Microglia may be involved in the cognitive impairment caused by general anesthesia.This review summarizes the development and activation process of microglia,the characteristics of the developing brain and the effects of microglia on developmental brain func‑tion.It is important to explore the regulation of microglia in the developing brain and their responses to specific anesthetics to reveal neurotoxicity induced by general anesthesia during the developmental period.

关 键 词：麻醉 全身 小胶质细胞 发育期大脑 神经毒性 

分 类 号：R614.2[医药卫生—麻醉学]