Ophthalmic manifestations in seropositive dengue fever patients during epidemics caused by predominantly different dengue serotypes  

作　　者：Ajeet M.Wagle Smita R.Hegde Srinivasan Sanjay Kah-Guan Au Eong 

机构地区：[1]International Eye Cataract Retina Centre,Mount Elizabeth Medical Centre,Singapore [2]International Eye Cataract Retina Centre,Farrer Park Medical Centre,Singapore [3]Khoo Teck Puat Hospital,Singapore [4]Alexandra Hospital,Singapore [5]Shree Shantinath Medical Trust-Jain Hospital,Mumbai,India [6]Narayana Nethralaya,Bangalore,India [7]Lee Kong Chian School of Medicine,Nanyang Technological University,Singapore

出　　处：《Advances in Ophthalmology Practice and Research》2022年第2期18-24,共7页眼科实践与研究新进展（英文）

摘　　要：Purpose:Dengue fever(DF)epidemics in Singapore in 2005–2006 and 2007 were caused predominantly by dengue virus serotypes 1(DENV-1)and 2(DENV-2)respectively.We investigated the prevalence of ophthalmic manifestations during these consecutive epidemics.Methods:Seropositive DF patients admitted to the hospital during two separate dengue epidemics were enrolled from June 2005 to December 2007.Demographic,ophthalmic,and laboratory data were collected.The primary outcome measures were differences in ophthalmic and laboratory features across the two epidemics.Factors associated with increased risk of developing various DF-related ophthalmic manifestations were the secondary outcome measures.Results:Of the 115 patients enrolled,109(94.7%;33 in 2005–2006 and 76 in 2007)completed the eye screening protocol.Majority of patients were Chinese(65,59.6%)and males(81,74.3%).The mean age was 40.8 years(range,18–87).Colour vision impairment(12 vs 14[36.4%vs 18.7%];P?0.04),cotton wool spots(10 vs 3[30.3%vs 3.9%];P<0.001),bleeding diathesis(7 vs 3[21.2%vs 3.9%];P?0.004)and abnormal liver function(mean alanine amino-transferase[150.2 U/L vs 68.28 U/L;P?0.001],mean aspartate amino-transferase[196.86 U/L vs 99.53 U/L;P?0.002],total protein[68.43 g/L vs 72.27 g/L;P?0.016],serum albumin[36.86 g/L vs 40.5 g/L;P?0.001])were noted more often in DF epidemics predominantly caused by DENV-1 compared to DENV-2.Conclusions:A higher prevalence of colour vision impairment,cotton wool spots,bleeding diathesis,and abnormal liver function was found in DF epidemics predominantly caused by DENV-1 compared to DENV-2.

关 键 词：Dengue fever Ophthalmic manifestations SEROTYPE Epidemic Singapore 

分 类 号：R51[医药卫生—内科学]