脐带间充质干细胞的生物学特性及旁分泌作用的研究进展  

Research Progress on the Biological Characteristics and Paracrine Effects of Umbilical Cord Mesenchymal Stem Cells

作　　者：陈小巧 牧仁[1] 李玉玲[1] CHEN Xiaoqiao;MU Ren;LI Yuling(College of Life Science and Technology,Inner Mongolia Normal University,Hohhot 010022,China)

机构地区：[1]内蒙古师范大学生命科学与技术学院,呼和浩特010022

出　　处：《生物技术进展》2022年第4期559-567,共9页Current Biotechnology

基　　金：国家自然科学基金项目(31260265);内蒙古自治区自然科学基金项目(2019MS08166)。

摘　　要：脐带是由胚胎外中胚层和/或胚胎中胚层发育而来的组织,脐带间充质干细胞是具有自我更新、多向分化以及高度增殖潜能的多功能干细胞。研究证明,脐带间充质干细胞具有以下功能:参与炎症反应,抑制炎症因子分泌并促进免疫调节;参与受损伤组织的治疗与修复使其再生并改善特定疾病症状;抑制肿瘤增殖和迁移以及促进其凋亡等。然而目前尚未明确以上功能是间充质干细胞本身发挥作用,还是其分泌的相关因子对机体修复产生作用。主要对脐带间充质干细胞的定义、来源、生物学特性、分泌功能等方面的研究进展进行了综述,旨在更好地利用间充质干细胞修复组织,以期为脐带间充质干细胞的后续研究提供参考依据。The umbilical cord is a tissue developed from the embryonic outer mesoderm and/or embryonic mesoderm.Umbilical cord mesenchymal stem cells are multifunctional stem cells with self-renewal,multi-directional differentiation and high proliferation potential.Studies have shown that umbilical cord mesenchymal stem cells have following functions:participating in inflammatory response,inhibiting the secretion of inflammatory factors and promoting immune regulation;participating in the treatment and repair of injured tissue to regenerate and improving the symptoms of specific diseases;inhibiting tumor proliferation and migration and promoting its apoptosis.However,it is not clear whether the mesenchymal stem cells themselves or the related factors secreted by mesenchymal stem cells were responsible for body repair.This article mainly reviewed the progress in the definition,source,biological characteristics and secretory function of umbilical cord mesenchymal stem cells,which aimed to make use of the ability of mesenchymal stem cells to repair tissue,and provide references for the follow-up research of umbilical cord mesenchymal stem cells.

关 键 词：脐带间充质干细胞 生物学特性 免疫调节 旁分泌作用 抗肿瘤 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]