3.0T磁共振1H-MRS代谢产物在脑胶质瘤分级诊断中的价值及其与Ki-67蛋白的相关分析  

The Value of Metabolites of 1H-MRS in 3.0T Magnetic Resonance Imaging in Grade Diagnosis of Brain Glioma and their Correlation with KI-67

作　　者：赵树立 邓克学 程传东 ZHAO Shu-li;DENG Ke-xue;CHENG Chuan-dong(Department of Radiology,the First Affiliated Hospital of University of Science and Technology of China,Hefei 230001,Anhui Province,China)

机构地区：[1]中国科学技术大学附属第一医院影像科,安徽合肥230001

出　　处：《中国CT和MRI杂志》2022年第8期4-5,14,共3页Chinese Journal of CT and MRI

摘　　要：目的探讨磁共振波谱分析(magnetic resonance spectroscopy,MRS)代谢产物在胶质瘤分级诊断中的价值及其与Ki-67蛋白的相关关系。方法回顾性分析2018年1月至2020年1月在我院经手术及病理证实的脑神经胶质瘤患者50例,其中低级别(WHOⅠ~Ⅱ级)胶质瘤25例、高级别(WHOⅢ~Ⅳ级)胶质瘤25例;低级别组男14例、女11例,平均年龄(48.64+11.76)岁;高级别组男19例、女6例,平均年龄(56.12+8.7)岁。所有患者术前均行3.0T磁共振1H-MRS检查,术后病理切片均行Ki-67蛋白染色观察。结果高级别胶质瘤组肿瘤实质中心区Cho/NAA、Cr/NAA值均高于低级别胶质瘤组,差异均有统计学意义(P<0.05),两组胶质瘤患者Ki-67蛋白染色均表达呈阳性,且Ki-67表达程度与Cho/NAA比值呈正相关。结论1H-MRS成像及术后Ki-67蛋白染色观察在脑胶质瘤术前分级诊断和术后治疗方案制定中有重要临床参考价值。Objective To explore the value of MAGNETIC resonance spectroscopy(MRS)in the diagnosis of glioma and the correlation of KI-67 protein.Methods 50 patients with cerebral glioma confirmed by surgery and pathology in our hospital from January 2018 to January 2020 were retrospectively analyzed,including 25 patients with glioma of low grade(WHOⅠ-Ⅱ)and 25 patients with glioma of high grade(WHOⅢ-Ⅳ).There were 14 males and 11 females in the lower grade group,with an average age of 48.64+11.76 years.There were 19 males and 6 females in the high-level group,with an average age of 56.12+8.7 years.All patients were examined by 3.0T MAGNETIC resonance 1H-MRS before surgery,and the postoperative pathological sections were observed by KI-67 protein staining.Results The values of Cho/NAA and Cr/NAA in the parenchymal center of the high-grade glioma group were higher than those of the low-grade glioma group,and the differences were statistically significant(P<0.05).Ki-67 protein staining was positive in both groups of glioma patients,and the expression level of KI67 was positively correlated with Cho/NAA ratio.Conclusion 1H-MRS imaging and postoperative KI-67 protein staining observation have important clinical reference value in preoperative grading diagnosis of glioma and the formulation of postoperative treatment plan.

关 键 词：1H-MRS 胶质瘤 KI-67 

分 类 号：R445.2[医药卫生—影像医学与核医学]