不同严重程度抑郁症患者SPECT/CT脑血流灌注显像特点分析  

SPECT/CT Cerebral Blood Perfusion Imaging Features of Patients with Different Severity of Depression

作　　者：蒲涛 许莉 蒲涛青 黄雪竹 郭倩 章家川 PU Tao;XU Li;PU Tao-qing;HUANG Xue-zhu;GUO Qian;ZHANG Jia-chuan(Department of Nuclear Medicine,Nanchong Central Hospital,Nanchong 637000,Sichuan Province,China)

机构地区：[1]南充市中心医院核医学科,四川南充637000

出　　处：《中国CT和MRI杂志》2022年第8期24-27,共4页Chinese Journal of CT and MRI

基　　金：南充市市校科技战略合作项目(19SXHZ0268)。

摘　　要：目的分析不同严重程度抑郁症者患者单光子发射计算机断层成像术(SPECT/CT)脑血流灌注显像特点。方法回顾性分析2020年1月至2020年12月南充市中心医院收治的70例抑郁症患者的临床资料,作为观察组,并选取70例健康志愿者作为对照组,根据汉密尔顿抑郁量表(HAMD)分为重度抑郁组(HAMD>24分,n=18)、中度抑郁组(HAMD=18~24,n=30)及轻度抑郁组(HAMD=7~17,n=22)。行SPECT/CT脑血流灌注显像,对比分析SPECT/CT脑血流灌注显像特征,探讨SPECT/CT脑血流灌注及显像对抑郁症是否具有诊断价值,比较不同严重程度患者局部脑血流量(rCBF)、标准化摄取值(SUV)、靶/非靶值(T/NT)和HAMD、汉密尔顿焦虑量表(HAMA)评分,并分析rCBF、SUV、T/NT与HAMD、HAMA的相关性。结果观察组额叶、基底节、丘脑放射性技术比值低于对照组(P<0.05);观察组rCBF、SUV、T/NT值高于对照组(P<0.05);rCBF、SUV、T/NT值联合预测抑郁症的敏感度、特异度及AUC面积均高于单独预测(P<0.05);重度抑郁组rCBF、SUV、T/NT值和HAMD、HAMA评分高于中度抑郁组和轻度抑郁组,中度抑郁组rCBF、SUV、T/NT值和HAMD、HAMA评分高于轻度抑郁组(P<0.05);Spearman相关分析显示,rCBF、SUV、T/NT值与HAMD、HAMA评分呈正相关性(P<0.05)。结论SPECT/CT脑血流灌注显像可评估抑郁症患者病情严重程度,能够为诊断和治疗提供参考。Objective To analyze the single photon emission computed tomography(SPECT/CT)cerebral blood perfusion imaging features of patients with different severity of depression.Methods 70 patients with depression who were admitted and treated in Nanchong Central Hospital from January to December 2020 were selected as the observation group.Meanwhile,70 healthy volunteers were selected as the control group.According to the Hamilton Depression Scale(HAMD)scores,the patients were divided into severe depression group(HAMD score>24 points,n=18),moderate depression group(HAMD score 18~24 points,n=30)and mild depression group(HAMD score 7~17 points,n=22).SPECT/CT cerebral blood perfusion imaging was performed,and SPECT/CT cerebral blood perfusion imaging features were comparatively analyzed.The value of SPECT/CT cerebral blood perfusion imaging in diagnosis of depression was evaluated.The regional cerebral blood flow(rCBF),standardized uptake value(SUV),target/non-target value(T/NT),HAMD and Hamilton Anxiety Scale(HAMA)scores of patients with different severity of depression were compared.The correlation between rCBF,SUV,T/NT and HAMD and HAMA scores was analyzed.Results The ratios of radioactive techniques in the frontal lobe,basal ganglia and thalamus of the observation group were lower than the control group(P<0.05).The rCBF,SUV and T/NT of the observation group were higher than those of the control group(P<0.05).The sensitivity,specificity and AUC of combination of rCBF,SUV and T/NT in prediction of depression were higher than those of single prediction(P<0.05).The rCBF,SUV,T/NT,HAMD and HAMA scores of severe depression group,moderate depression group and mild depression group decreased in turn(P<0.05).Spearman correlation analysis showed that rCBF,SUV and T/NT were positively correlated with HAMD and HAMA scores(P<0.05).Conclusion SPECT/CT cerebral blood perfusion imaging can be used to assess the severity of depression and provide reference for diagnosis and treatment.

关 键 词：抑郁症 不同严重程度 SPECT/CT 脑血流灌注显像 

分 类 号：R445.3[医药卫生—影像医学与核医学]