初诊小细胞肺癌(SCLC)分期及预后评价中^(18)F-FDG PET/CT的价值  

Evaluation Value of^(18)F-FDG PET/CT in The Staging And Prognosis of Firstly Diagnosed Small Cell Lung Cancer(SCLC)

作　　者：邵俊伟[1] 潘学兵[1] 袁志鹏 何宇[1] SHAO Jun-wei;PAN Xue-bing;YUAN Zhi-peng;HE Yu(Department of Oncology,Dongguan People's Hospital,Dongguan 523000,GuangdongProvince,China)

机构地区：[1]东莞市人民医院肿瘤内科,广东东莞523000

出　　处：《中国CT和MRI杂志》2022年第8期71-73,共3页Chinese Journal of CT and MRI

摘　　要：目的探讨^(18)氟脱氧葡萄糖-正电子发射计算机断层扫描(^(18)F-FDG PET/CT)对初诊小细胞肺癌(SCLC)分期、预后的评估价值。方法回顾分析2017年1月至2019年3我院收治初次确诊为SCLC并接受^(18)F-FDG PET/CT检测的60例患者临床资料,根据^(18)F-FDG PET/CT检查结果并采用美国退伍军人医院制定的局限期(LD)/广泛期(ED)分期法记录LD期、ED期患者分布情况,分析比较LD/ED分期与TNM分期一致性。根据LD/ED分期将SCLC患者分为ED组、LD组,比较两组患者原发病灶^(18)F-FDG PETCT检测最高标准摄取值(SUV_(max)),采用Kaplan-Meier生存分析SUV_(max)对SCLC患者预后的评估价值。结果与经典肿瘤临床分期相比,^(18)F-FDG PET/CT检查对SCLC患者LD期诊断的灵敏度为96.88%,特异度为82.14%,kappa值为0.797。ED组、LD组患者的SUV_(max)分别为10.88±3.1、12.16±2.98,差异比较无统计学意义(P>0.05);60例SCLC患者进展35例,死亡28例,存活率为53.33%,疾病无进展生存时间为10.20个月;LD期、ED期患者1年存活率分别为63.89%、37.50%,两组患者整体生存时间比较差异无统计学意义(P>0.05),而疾病无进展生存分析比较差异有统计学意义(P<0.05)。SUV_(max)≥11.22组死亡16例,SUV_(max)<11.22组患者死亡12例,总生存率分别为48.39%、58.62%,两组患者疾病无进展中位生存时间分别为9.50个月、10.50个月,差异无统计学意义(P>0.05)。结论^(18)F-FDG PET/CT对初诊SCLC分期具有一定诊断价值,但对患者预后评估价值有待研究。Objective To explore evaluation value of 18F-fluorodeoxyglucose positron-emission tomography/computed tomography(^(18)F-FDG PETCT)in the staging and prognosis of firstly diagnosed small cell lung cancer(SCLC).Methods The clinical data of 60 patients firstly diagnosed with SCLC who underwent ^(18)F-FDG PET/CT and were admitted to the hospital from January 2017 to March 2019 were retrospectively analyzed.According to examination results of ^(18)F-FDG PET/CT,distributions of patients in limited disease(LD)and extensive disease(ED)stages were recorded by LD/ED staging method formulated by the American Veterans Hospital.The consistency between LD/ED staging and TNM staging was analyzed and compared.According to LD/ED staging,SCLC patients were divided into ED group and LD group.The maximum standardized uptake values(SUV_(max))of primary lesions by^(18)F-FDG PET/CT test were compared between the two groups.Results Compared with classical clinical staging of tumors,the sensitivity,specificity and kappa value of ^(18)F-FDG PET/CT for the diagnosis of LD stage in SCLC patients were 96.88%,82.14%and 0.797,respectively.There was no significant difference in SUV_(max)between ED group and LD group(10.88±3.1 vs 12.16±2.98)(P>0.05).Of the 60 SCLC patients,there were 35 cases in advanced period and 28 cases died.The survival rate and progression-free survival(PFS)were 53.33%and10.20 months,respectively.The 1-year survival rates in LD and ED patients were 63.89%and 37.50%,respectively.There was no significant difference in overall survival time between the two groups(P>0.05),while differences in PFS were statistically significant(P<0.05).There were 16 cases and 12 cases died in SUV_(max)≥11.22 group and SUV_(max)<11.22 group,respectively.The overall survival rates in the two groups were 48.39%and 58.62%,respectively.The median disease-free survival time in the two groups was 9.50 months and 10.50 months,respectively(P>0.05).Conclusion^(18)F-FDG PET/CT is of certain diagnostic value in the staging of firstly diagnosed SCLC.How

关 键 词：小细胞肺癌 18氟脱氧葡萄糖 正电子发射计算机断层扫描 分期 预后 

分 类 号：R322.35[医药卫生—人体解剖和组织胚胎学]