氯化锰口服溶液应用于磁共振胰胆管成像(MRCP)的临床研究  

Clinical Study on the Application of Oral Solution of Manganese Chloride in Magnetic Resonance Cholangiopancreatography(MRCP)

作　　者：王鹏[1] 彭明洋 马跃虎[1] 任军[1] 王利伟[1] 武新英[1] 冯源[1] 殷信道[1] WANG Peng;PENG Ming-yang;MA Yue-hu;REN Jun;WANG Li-wei;WU Xin-ying;FENG Yuan;MAO Cun-nan;YIN Xin-dao(Department of Medical Imaging,Nanjing Hospital Affiliated to Nanjing Medical University(Nanjing First Hospital),Nanjing 210006,Jiangsu Province,China)

机构地区：[1]南京医科大学附属南京医院(南京市第一医院)医学影像科,江苏南京210006

出　　处：《中国CT和MRI杂志》2022年第8期123-125,132,共4页Chinese Journal of CT and MRI

摘　　要：目的研究氯化锰口服溶液作为口服胃肠道阴性造影剂在MRCP检查中的临床应用意义。方法采用自身对照方法研究30例患者口服氯化锰溶液前、后分别行MRCP检查的图像质量改变及通过对临床症状、体征及相关实验室检查判断实验安全性。结果口服氯化锰溶液后胃与十二指肠内液体的高信号基本被抑制,减少或消除了胃肠道内高信号的干扰,MRCP图像质量Likert5分量表法显示及各项评分优良率比较在服对比剂前后具有统计学意义(P<0.05)。口服氯化锰溶液后无不适反应及与试验药物有关的严重不良反应。结论口服氯化锰溶液作为胃肠道阴性对比剂可以安全有效地改善MRCP的图像质量。Objective To study the clinical significance of oral manganese chloride solution as a negative contrast agent for oral gastrointestinal tract in magnetic resonance cholangiopancreatography(MRCP)examination.Methods The self-control method was used to study the image quality changes of MRCP before and after oral administration of manganese chloride solution in 30 patients,and the clinical symptoms,signs and related laboratory tests were used to judge the experimental safety.Results After oral administration of manganese chloride solution,the high signal of gastric and duodenum liquid was basically inhibited,and the interference of high signal in gastrointestinal tract was reduced or eliminated.The MRCP image quality Likert5 subscale and the comparison of the excellent and good rate of each score had statistical significance before and after taking the contrast agent(P<0.05).There was no discomfort and serious adverse reactions related to the test drug.Conclusion Oral administration of manganese chloride solution as a negative contrast agent for gastrointestinal tract can safely and effectively improve the image quality of MRCP.

关 键 词：磁共振胰胆管成像 对比剂 氯化锰口服溶液 

分 类 号：R445.2[医药卫生—影像医学与核医学] R575.6[医药卫生—诊断学]