A Mg^(2+)/polydopamine composite hydrogel for the acceleration of infected wound healing  

作　　者：Zhaoyuan Guo Zhuangzhuang Zhang Nan Zhang Wenxia Gao Jing Li Yuji Pu Bin He Jing Xie 

机构地区：[1]College of Chemistry and Materials Engineering,Wenzhou University,Wenzhou,325035,China [2]National Engineering Research Center for Biomaterials,College of Biomedical Engineering,Sichuan University,Chengdu,610065,China [3]Department of Stomatology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China

出　　处：《Bioactive Materials》2022年第9期203-213,共11页生物活性材料（英文）

基　　金：supported by the National Natural Science Foundation of China(No.51773130,52073216 and 51903172);National Science Foundation of Zhejiang province(LY20B040004).

摘　　要：Bacterial infection is a vital factor to delay the wound healing process.The antibiotics abuse leads to drug resistance of some pathogenic bacteria.Non-antibiotic-dependent multifunctional biomaterials with accelerated wound healing performance are urgently desired.Herein,we reported a composite antibacterial hydrogel PDA-PAM/Mg^(2+)that shows excellent self-healing and tissue adhesive property,and photothermal antibacterial functions for accelerating wound healing.The gel was composed of polyacrylamide(PAM),polydopamine(PDA),and magnesium(Mg^(2+))and prepared via a two-step procedure:an alkali-induced dopamine pre-polymerization and followed radical polymerization process.The composite gel shows excellent tissue adhesiveness and Mg^(2+)-synergized photothermal antibacterial activity,inducing a survival rate of 5.29% for S.aureus and 7.06%for E.coli after near infrared light irradiation.The composite hydrogel further demonstrated efficient bacteria inhibition,enhanced wound healing and collagen deposition in a full-thickness skin defect rat model.Together,the PDA-PAM/Mg^(2+) hydrogel presents an excellent wound dressing with excellent tissue adhesion,wound healing,and antibacterial functions.

关 键 词：Multifunctional hydrogel SELF-HEALING Tissue adhesiveness Photothermal antibacterial effect Wound healing 

分 类 号：R318.08[医药卫生—生物医学工程] TQ427.26[医药卫生—基础医学]