Thermal activation of Ti_((1-x))Au_((x))thin films with enhanced hardness and biocompatibility  

作　　者：Cecil Cherian Lukose Ioannis Anestopoulos Theodora Mantso Leon Bowen Mihalis I.Panayiotidis Martin Birkett 

机构地区：[1]Department of Mechanical and Construction Engineering,Northumbria University,Newcastle Upon Tyne,UK [2]Department of Cancer Genetics,Therapeutics&Ultrastructural Pathology,The Cyprus Institute of Neurology and Genetics,Nicosia,Cyprus [3]The Cyprus School of Molecular Medicine,The Cyprus Institute of Neurology and Genetics,Nicosia,Cyprus [4]Department of Applied Sciences,Northumbria University,Newcastle Upon Tyne,UK [5]Department of Physics,G.J.Russell Microscopy Facility,Durham University,Durham,UK

出　　处：《Bioactive Materials》2022年第9期426-445,共20页生物活性材料（英文）

基　　金：funded and supported by the Leverhulme Trust Research Project Grant(RPG-2018-344)。

摘　　要：The lifetime of orthopaedic implants can be extended by coating the softer Ti6Al4V alloy with harder biocompatible thin films.In this work,thin films of Ti_((1-x))Au_((x))are grown on Ti_(6)Al_(4)V and glass substrates by magnetron sputtering in the entire x=0-1 range,before their key biomechanical properties are performance tuned by thermal activation.For the first time,we explore the effect of in-situ substrate heating versus ex-situ post-deposition heat-treatment,on development of mechanical and biocompatibility performance in Ti-Au films.A~250% increase in hardness is achieved for Ti-Au films compared to bulk Ti6Al4V and a~40%improvement from 8.8 GPa as-grown to 11.9 and 12.3 GPa with in-situ and ex-situ heat-treatment respectively,is corelated to changes in structural,morphological and chemical properties,providing insights into the origins of super-hardness in the Ti rich regions of these materials.X-ray diffraction reveals that as-grown films are in nanocrystalline states of Ti-Au intermetallic phases and thermal activation leads to emergence of mechanically hard Ti-Au intermetallics,with films prepared by in-situ substrate heating having enhanced crystalline quality.Surface morphology images show clear changes in grain size,shape and surface roughness following thermal activation,while elemental analysis reveals that in-situ substrate heating is better for development of oxide free Ti3Auβ-phases.All tested Ti-Au films are non-cytotoxic against L929 mouse fibroblast cells,while extremely low leached ion concentrations confirm their biocompatibility.With peak hardness performance tuned to>12 GPa and excellent biocompatibility,Ti-Au films have potential as a future coating technology for load bearing medical implants.

关 键 词：Ti-Au thin film coating HARDNESS Biocompatible L929 mouse fibroblast Implants 

分 类 号：R318[医药卫生—生物医学工程] R62[医药卫生—基础医学]