Microencapsulated essential oils combined with organic acids improves immune antioxidant capacity and intestinal barrier function as well as modulates the hindgut microbial community in piglets  

作　　者：Jiayu Ma Shenfei Long Jian Wang Jie Gao Xiangshu Piao 

机构地区：[1]State Key Laboratory of Animal Nutrition,College of Animal Science and Technology,China Agricultural University,Beijing 100193,China [2]Institute of Animal Sciences,Chinese Academy of Agricultural Sciences,Beijing 100193,China.

出　　处：《Journal of Animal Science and Biotechnology》2022年第4期1126-1142,共17页畜牧与生物技术杂志（英文版）

基　　金：supported by the National Natural Science Foundation of China(31772612);Beijing Municipal Natural Science Foundation(6202019).

摘　　要：Background:The objective of this experiment was to evaluate the effect of a combination of microencapsulated essential oils and organic acids(MOA)on growth performance,immuno-antioxidant status,intestinal barrier function and microbial structure of the hindgut in piglets.A total of 120 piglets(Duroc×[Landrace×Yorkshire];weighted 7.66±1.79 kg,weaned at d 28)were randomly selected and allocated to 3 treatments with 4 replicates per group and 10 piglets per replicate according to the initial body weight and gender.The dietary treatments were as follows:1)basal diet(Ctrl);2)Ctrl+chlortetracycline(75 mg/kg)(AGP);3)Ctrl+MOA(1500 mg/kg).The experiment period was lasted for 21 d.Results:Compared to the Ctrl group,dietary supplemented MOA alleviated(P<0.05)the diarrhea rate from d 12 to 21,enhanced(P<0.05)the concentration of serum interlukin-10 and glutathione peroxidase in piglets on d 11 after weaning and serum superoxide dismutase in 21-day piglets.The MOA group also improved(P<0.05)the apparent digestibility of dry matter(DM),organic matter(OM)and gross energy(GE),up-regulated(P<0.05)the mRNA expression level of occludin,claudin-1 and mucin-2 in ileum and increased(P<0.05)the contents of propionic and butyric acids in the cecum of piglets.The MOA group modulated the cecal and colonic microbial community structure and increased(P<0.05)the abundance of Faecalibacterium and Muribaculaceae in cecum and Streptococcus and Weissella in colon.Additionally,AGP group decreased(P<0.05)apparent digestibility of DM,OM and GE as well as down-regulated(P<0.05)relative gene expression level of claudin-1 in duodenum and jejunum,ZO-1 and mucin-1 in jejunum of piglets.Conclusion:In summary,dietary supplemented MOA alleviated diarrhea and improved nutrient apparent digestibility in piglets via enhancing immuno-antioxidant properties,increasing digestive enzyme activity,upregulating the expression of intestinal barrier-related genes,and modifying the microbial community structure of the cecum and colon.Therefore,dietary supplementatio

关 键 词：Essential oil Gut microbiota Intestinal barrier Mixed organic acid PIGLETS 

分 类 号：S828.5[农业科学—畜牧学]