注射用丹参多酚酸盐对老年急性冠脉综合征心肌损伤标志物及炎症因子水平影响  

Effects of Salvianolate Injection on Myocardial Injury Markers and Inflammatory Factors in Senile Acute Coronary Syndrome

作　　者：金玉[1] 张宁[1] JIN Yu;ZHANG Ning(Department of Hypertension,Zhengzhou people's Hospital,Zhengzhou Henan 450000,China)

机构地区：[1]郑州人民医院高血压科,河南郑州450000

出　　处：《临床研究》2022年第8期115-118,共4页Clinical Research

摘　　要：目的观察丹参多酚酸盐对老年急性冠脉综合征(ACS)心肌损伤标志物及炎症因子水平的影响。方法选取2019年8月至2020年7月郑州人民医院老年ACS患者109例,按治疗方案不同分治疗组(56例)、常规组(53例)。常规组采用常规治疗,治疗组基于常规组加用丹参多酚酸盐,对比两组疗效、血清心肌损伤标志物[肌酸激酶(CK)、脑钠尿肽(BNP)、肌酸激酶同工酶(CK-MB)]水平、炎症因子[白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)]、不良心血管事件发生率、血小板活化功能(血小板膜糖蛋白CD63、CD62p)水平及不良反应。结果治疗组有效率(96.43%)高于常规组(81.13%),差异有统计学意义(P<0.05);治疗后血清CK、CK-MB、BNP水平降低,治疗组低于常规组,差异有统计学意义(P<0.05);治疗后血清IL-6、hs-CRP水平降低,治疗组低于常规组,差异有统计学意义(P<0.05);治疗后,两组血小板膜糖蛋白CD62p、CD63水平均降低,且治疗组低于常规组,差异有统计学意义(P<0.05);治疗后,治疗组不良心血管事件发生率低于常规组,差异有统计学意义(P<0.05);两组治疗过程中均未见不良反应。结论注射用丹参多酚酸盐治疗老年ACS能通过减轻炎症反应,保护心肌细胞,抑制血小板活化,提高治疗效果,降低不良心血管事件发生率。Objective To investigate the effect of salvianolate injection on the levels of myocardial injury markers and inflammatory factors in elderly patients with acute coronary syndrome(ACS).Methods A total of 109 elderly patients with ACS in Zhengzhou People's Hospital from August 2019 to July 2020 were selected and divided into treatment group(56 cases)and routine group(53 cases)according to different treatment regimens.The conventional treatment group received conventional treatment,and the treatment group received salvianolate based on the conventional treatment.Efficacy,serum levels of myocardial injury markers[CK,BNP,CK-MB],inflammatory factors[INTERleukin-6(IL-6),hypersensitive C-reactive protein(HSCRP)],incidence of adverse cardiovascular events and platelet activation function(PLATELET membrane glycoprotein CD63),CD62p and adverse reactions were compared between two groups.Results The effective rate of the treatment group was 96.43%higher than that of the conventional group(81.13%),and the difference was statistically significant(P<0.05).After treatment,the serum LEVELS of CK,CK-MB and BNP decreased,and the treatment group was lower than the conventional group,the difference was statistically significant(P<0.05).After treatment,serum IL-6 and Hs-CRP levels were decreased,and the treatment group was lower than the conventional group,the difference was statistically significant(P<0.05).After treatment,the levels of PLATELET membrane glycoproteins CD62p and CD63 were decreased in both groups,and the treatment group was lower than the conventional group,the difference was statistically significant(P<0.05).After treatment,the incidence of adverse cardiovascular events in the treatment group was lower than that in the conventional group,the difference was statistically significant(P<0.05).There were no adverse reactions in both groups.Conclusion The treatment of senile ACS with salvia miltiorrhiza polyphenols for injection can improve the therapeutic effect and reduce the incidence of adverse cardiovascular events by

关 键 词：注射用丹参多酚酸盐 老年 心肌损伤标志物 炎症因子 白细胞介素-6 急性冠脉综合征 

分 类 号：R541.4[医药卫生—心血管疾病]