抗病毒治疗疗程时间对IM患儿EBV抑制及复发率的影响  

The effect of antiviral treatment time on EBV inhibition and recurrence rate in IM children

作　　者：余永波 王国平 聂优华 李国辉[1] 吴海泉[1] Yu Yongbo;Wang Guoping;Nie Youhua(The People's Hospital of Shanggao County,Shanggao,Jiangxi 336400)

机构地区：[1]上高县人民医院,江西上高336400

出　　处：《基层医学论坛》2022年第23期1-3,22,共4页The Medical Forum

基　　金：宜春市科技计划项目(JXYC2021KSA15)。

摘　　要：目的研究抗病毒治疗疗程时间对传染性单核细胞增多症(infectious mononucleosis,IM)患儿EBV抑制及复发率的影响。方法以2020年1月-12月上高县人民医院收治的80例IM患儿为研究对象,随机分为观察组、对照组各40例,对照组应用长疗程抗病毒治疗,观察组用短疗程抗病毒治疗。对比2组症状缓解时间、EBV抑制率、复发率、不良反应发生率。结果2组咽峡炎、脾肿大、肝肿大、淋巴结肿大消退时间及退热时间均无统计学差异(P>0.05).观察组治疗后6个月EBV-DNA.EBV CA-IgM阳性率分别为7.50%,5.00%,均与对照组的5.00%,0.00%无统计学差异(P>0.05).2组治疗后T淋巴细胞CD_(3)、CD_(8)均低于组内治疗前(P<0.05),T淋巴细胞CD_(4),CD_(4)/CD_(8)水平均高于组内治疗前(P<0.05),观察组治疗后T淋巴细胞CD_(3)、CD_(8)、CD_(4)、CD_(4)/CD_(8)水平与对照组均无统计学差异(P>0.05).观察组治疗后6个月内EM复发率为5.00%,与对照组的2.50%比较无统计学差异(P>0.05).观察组治疗期间不良反应发生率为7.50%,低于对照组的25.00%(P<0.05).结论短疗程抗病毒治疗能获得与长疗程抗病毒治疗接近的效果,且能减少不良反应发生率,可发挥良好保效减毒效果,值得推广。Objective To study the effect of antiviral treatment time on EBV suppression and recurrence rate in children with IM.Methods 80 cases of IM children admitted to our hospital from January 2020 to December 2020 were taken as the research objects.They were randomly divided into an observation group and a control group with 40 cases each.The control group received long-term antiviral therapy,and the observation group received short-term antiviral therapy.The course of antiviral treatment was used to compare the symptom relief time,EBV inhibition rate,recurrence rate,and incidence of adverse reactions between the two groups.Results There was no significant difference between the observation group and the control group for angina,splenomegaly,hepatomegaly,lymphadenopathy,time to subsidence and fever reduction time(P>0.05).The positive rates of EBV-DNA and EBV CA-IgM in the observation group at 6 months after treatment were 7.50%and 5.00%,respectively,which were not statistically different from those in the control group at 5.00%and 0.00%(P>0.05).T lymphocyte CD_(3),CD_(8) were lower in both observation group and control than before treatment(P<0.05),and CD_(4),CD_(4)/CD_(8) of C lymphocytes were higher than before treatment(P<0.05).After observation treatment,CD_(3),CD_(8),CD_(4),CD_(4)/CD_(8)(P>0.05).The recurrence rate of EM in the observation group within 6 months after treatment was 5.00%,which was not statistically different from 2.50%in the control group(P>0.05).The incidence of adverse reactions during treatment in the observation group was 7.50%,which was lower than 25.00%in the control group(P<0.05).Conclusion Short-course antiviral therapy can achieve similar effects to long-term antiviral therapy,and can reduce the incidence of adverse reactions,and can play a good effect of maintaining efficacy and reducing toxins.It is worthy of promotion.

关 键 词：传染性单核细胞增多症 抗病毒治疗 疗程时间 EBV抑制 复发率 

分 类 号：R557[医药卫生—血液循环系统疾病]