Microbial resistance to nanotechnologies:An important but understudied consideration using antimicrobial nanotechnologies in orthopaedic implants  

作　　者：Zhuoran Wu Brian Chan Jessalyn Low Justin Jang Hann Chu Hwee Weng Dennis Hey Andy Tay 

机构地区：[1]Institute of Health Innovation&Technology,National University of Singapore,117599,Singapore [2]Department of Biomedical Engineering,National University of Singapore,117583,Singapore [3]Biosafety Level 3 Core Facility,Yong Loo Lin School of Medicine,National University of Singapore,117599,Singapore [4]Department of Microbiology and Immunology,Yong Loo Lin School of Medicine,National University of Singapore,117545,Singapore [5]Infectious Disease Programme,Yong Loo Lin School of Medicine,National University of Singapore,117547,Singapore [6]Institute of Molecular and Cell Biology,35 Agency for Science,Technology and Research,138673,Singapore [7]National University Health System,National University of Singapore,119228,Singapore [8]Tissue Engineering Programme,National University of Singapore,117510,Singapore

出　　处：《Bioactive Materials》2022年第10期249-270,共22页生物活性材料（英文）

基　　金：funding support from the NUS Presidential Young Professorship and NUS Technological Innovations in Infectious Diseases Translational Research.

摘　　要：Microbial resistance to current antibiotics therapies is a major cause of implant failure and adverse clinical outcomes in orthopaedic surgery.Recent developments in advanced antimicrobial nanotechnologies provide numerous opportunities to effective remove resistant bacteria and prevent resistance from occurring through unique mechanisms.With tunable physicochemical properties,nanomaterials can be designed to be bactericidal,antifouling,immunomodulating,and capable of delivering antibacterial compounds to the infection region with spatiotemporal accuracy.Despite its substantial advancement,an important,but under-explored area,is potential microbial resistance to nanomaterials and how this can impact the clinical use of antimicrobial nanotechnologies.This review aims to provide a better understanding of nanomaterial-associated microbial resistance to accelerate bench-to-bedside translations of emerging nanotechnologies for effective control of implant associated infections.

关 键 词：Bacterial infection Orthopaedic implant Microbial resistance NANOMATERIAL Antimicrobial nanotechnology 

分 类 号：R68[医药卫生—骨科学] R318[医药卫生—外科学]