Sudoku of porous, injectable calcium phosphate cements – Path to osteoinductivity  

作　　者：Agneta Vezenkova Janis Locs 

机构地区：[1]Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre of RTU,Institute of Genera Chemical Engineering,Faculty of Materials Science and Applied Chemistry,Riga Technical University,Pulka Street 3,LV-1007,Riga,Latvia [2]Baltic Biomaterials Centre of Excellence,Headquarters at Riga Technical University,Riga,Latvia

出　　处：《Bioactive Materials》2022年第11期109-124,共16页生物活性材料（英文）

基　　金：The authors acknowledge financial support for granting Open Access from the European Union’s Horizon 2020 research and innovation programme under the grant agreement No.857287.

摘　　要：With the increase of global population,people’s life expectancy is growing as well.Humans tend to live more active lifestyles and,therefore,trauma generated large defects become more common.Instances of tumour resection or pathological conditions and complex orthopaedic issues occur more frequently increasing necessity for bone substitutes.Composition of calcium phosphate cements(CPCs)is comparable to the chemical structure of bone minerals.Their ability to self-set and resorb in vivo secures a variety of potential applications in bone regeneration.Despite the years-long research and several products already reaching the market,finding the right properties for calcium phosphate cement to be osteoinductive and both injectable and suitable for clinical use is still a sudoku.This article is focused on injectable,porous CPCs,reviewing the latest developments on the path toward finding osteoinductive material,which is suitable for injection.

关 键 词：Calcium phosphate cements Bone cements Bone regeneration OSTEOINDUCTIVITY 

分 类 号：R318[医药卫生—生物医学工程] R68[医药卫生—基础医学]