A self-crosslinking,double-functional group modified bacterial cellulose gel used for antibacterial and healing of infected wound  

作　　者：Yajie Xie Kun Qiao Lina Yue Tao Tang Yudong Zheng Shihui Zhu Huiyi Yang Ziyuan Fang 

机构地区：[1]School of Material Science and Engineering,University of Science and Technology Beijing,Beijing,China [2]Hebei Key Laboratory of Hazardous Chemicals Safety and Control Technology,School of Chemical and Environmental Engineering,North China Institute of Science and Technology,Langfang,065201,Hebei,China [3]Department of Burn Surgery,The First Affiliated Hospital of Naval Medical University,Shanghai,200433,China

出　　处：《Bioactive Materials》2022年第11期248-260,共13页生物活性材料（英文）

基　　金：This work was financially supported by National Natural Science Foundation of China(Grant No.51973018,51773018);Beijing Munic-ipal Science and Technology Commission Projects(No.Z191100002019017);Key Research and Development Projects of Peo-ple’s Liberation Army(BWS17J036);National Key Research and Development Project(No.2019yfa0110603);Program for the Top Young Talents of Higher Learning Institutions of Hebei(BJ2021096);The fellowship of China Postdoctoral Science Foundation(No.2020T130005ZX).

摘　　要：Cellulose/chitosan composite,as a mature commercial antibacterial dressing,is an important type of wound repair material.However,how to achieve the perfect compound of two components and improve antibacterial activity is a major,lingering issue.In this study,a bifunctional group modified bacterial cellulose(DCBC)was prepared by carboxymethylation and selective oxidation.Further,the chitosan(CS)was compounded in the network of DCBC by self-crosslinking to form dialdehyde carboxymethyl bacterial cellulose/chitosan composites(S-DCBC/CS).The aldehyde group can react with amino of CS by Schiff base reaction.The carboxyl group of DCBC and the amorphous distribution of CS molecular chains increase the antimicrobial properties of com-posites.The bacteriostatic rate of composites could be higher than 95%.Bacteria can be attracted onto the surface of composites,what we call it“directional adhesion antibacterial effects”.In particular,a kind of large animal wound model,deep II degree infected scald of Bama miniature pig,was used to research the antimicrobial and healing properties of materials.The S-DCBC/CS can effectively inhibit bacterial proliferation of wound and kill the bacteria.The wound healing rate of S-DCBC/CS was up to 80%after three weeks.The composites show better antibacterial and promoting concrescence effects than traditional chitosan dressings.

关 键 词：SELF-CROSSLINKING Bacterial cellulose Cell migration Wound healing Antimicrobial properties 

分 类 号：R318[医药卫生—生物医学工程]