胎膜早破孕妇HCMV、GBS、HPV、MG、UU、CT感染对妊娠结局的影响  

Effects of HCMV,GBS,HPV,MG,UU and CT infections on pregnancy outcomes in pregnant women with premature rupture of membrane

作　　者：李香钟 秦凤 LI Xiangzhong;QIN Feng(Department of Clinical Laboratory,the First People's Hospital of Zhengyuan County,Department of Obstetrics,the First People's Hospital of Zhengyuan County,Qingyang,Gansu,China,744500)

机构地区：[1]镇原县第一人民医院检验科/镇原县第一人民医院产科,甘肃庆阳744500

出　　处：《分子诊断与治疗杂志》2022年第7期1109-1112,1116,共5页Journal of Molecular Diagnostics and Therapy

摘　　要：目的 分析胎膜早破孕妇人巨细胞病毒(HCMV)、B族链球菌(GBS)、人乳头瘤病毒(HPV)、生殖道支原体(MG)、解脲脲原体(UU)、沙眼衣原体(CT)感染对妊娠结局的影响,为临床预防胎膜早破及妊娠结局的改善提供依据。方法 选取2020年6月至2021年12月镇原县第一人民医院产科收治的胎膜早破孕妇、及同期正常孕妇各200例,采用PCR-荧光探针法和RNA恒温扩增法检测HCMV、GBS、HPV、MG、UU、CT,比较各组感染情况,及胎膜早破孕妇HCMV、GBS、HPV、MG、UU、CT感染的妊娠结局。结果 胎膜早破组孕妇HCMV、GBS、HPV、MG、UU、CT的感染率显著高于对照组,差异有统计学意义(P均<0.05),其中UU的感染率最高(39.50%),MG的感染率最低(2.50%)。两种病原体同时感染的感染率相对较高,其中HPV+UU的感染率最高(16.00%),而HCMV+CT感染率最低(3.00%)。胎膜早破孕妇HCMV感染组早产、宫内感染、低体重儿、新生儿窒息、新生儿感染的发生率显著高于未感染组,差异有统计学意义(P均<0.05);GBS感染组早产、宫内感染、产后出血、绒毛膜羊膜炎、低体重儿、新生儿窒息、新生儿感染的发生率显著高于未感染组,差异有统计学意义(P均<0.05);HPV感染组早产、宫内感染、产后出血、低体重儿的发生率显著高于未感染组,差异有统计学意义(P均<0.05);MG、UU、CT感染组早产、宫内感染、产后出血、低体重儿、新生儿感染的发生率显著高于未感染组,差异有统计学意义(P均<0.05)。结论 孕妇HCMV、GBS、HPV、MG、UU、CT的感染与胎膜早破的发生有关,而HCMV、GBS、HPV、MG、UU、CT感染可能会增加胎膜早破孕妇不良妊娠结局风险。Objective To explore the influence of human cytomegalovirus(HCMV),group B streptococcus(GBS),human papillomavirus(HPV),mycoplasma genitalium(MG),ureaplasma urealyticum(UU)and chlamydia trachoma(CT)infections on pregnancy outcomes in pregnant women with premature rupture of membrane(PROM). Methods 200 pregnant women with PROM admitted to the Department of Obstetrics in the First People’s Hospital of Zhengyuan County from June 2020 to December 2021 were enrolled as the PROM group,and 200 normal pregnant women without PROM during the same period were randomly selected as the control group.With fluorescent quantitative polymerase chain reaction and RNA isothermal amplification to detect the HCMV,GBS,HPV,MG,UU,CT. The infection of each group was compared,the pregnant outcomes were followed. Results The infection rates of HCMV,GBS,HPV,MG,UU and CT in pregnant women with premature rupture of membranes were significantly higher than those in the control group(P<0.05),and the UU was the highest(39.50%),the MG was the lowest(2.50%). The infection rate of both pathogens is relatively high,and the infection rate of HPV+UU was the highest(16.00%),while that of HCMV+CT was the lowest(3.00%). The incidence of premature delivery,intrauterine infection,low birth weight infants,neonatal asphyxia and neonatal infection in the HCMV infected group was significantly higher than that in the uninfected group,the difference was statistically significant(P<0.05). The incidence of premature delivery,intrauterine infection,postpartum hemorrhage,chorioamnionitis,low birth weight infants,neonatal asphyxia and neonatal infection in the GBS infection group were significantly higher than those in the uninfected group,the difference was statistically significant(P<0.05). The incidence of premature delivery,intrauterine infection,postpartum hemorrhage and low birth weight infants in the HPV infected group was significantly higher than that in the uninfected group,the difference was statistically significant(P<0.05). The incidence of premature de

关 键 词：HCMV GBS HPV MG UU CT 胎膜早破 妊娠结局 

分 类 号：R714.433[医药卫生—妇产科学]