T2DM合并甲状腺功能减退症IGF-1、ApoB及hs-CRP与甲状腺激素的关系  

Relationship between IGF-1,ApoB,Hs-CRP and thyroid hormone in T2DM combined with hypothyroidism

作　　者：万明[1] 王家丽[1] 姚婷[1] 叶昱 WAN Ming;WANG Jiali;YAO Ting;YE Yu(Department of Endocrinology,the 2ND Affiliated Hospital of Chengdu Medical College.Nuclear Industry 416 Hospital,Chengdu,Sichuan,China,610000;Department of Outpatient,the 2ND Affiliated Hospital of Chengdu Medical College.Nuclear Industry 416 Hospital,Chengdu,Sichuan,China,610000)

机构地区：[1]成都医学院附属第二医院·核工业四一六医院内分泌科,四川成都610000 [2]成都医学院附属第二医院·核工业四一六医院门诊部,四川成都610000

出　　处：《分子诊断与治疗杂志》2022年第7期1175-1178,共4页Journal of Molecular Diagnostics and Therapy

基　　金：四川省卫生和计划生育委员会科研课题(19PJ232)。

摘　　要：目的 分析2型糖尿病(T2DM)合并甲状腺功能减退(SCH)胰岛素样生长因子1(IGF-1)、载脂蛋白B(ApoB)、超敏C反应蛋白(hs-CRP)与甲状腺激素[促甲状腺激素(TSH)、游离三碘甲腺原氨酸(FT3)、游离四碘甲腺原氨酸(FT4)]的关系。方法 收集2019年3月至2021年3月成都医学院附属第二医院门诊收治的88例T2DM合并SCH患者(观察组),根据患者SCH严重程度不同分为轻度56例,重度32例。另选取本院同期收治的86例单纯T2DM患者作为对照组。比较不同人群及不同病情程度患者IGF-1、ApoB、hs-CRP、甲状腺激素水平,Pearson分析IGF-1、ApoB、hs-CRP与甲状腺激素的相关性。结果 观察组IGF-1、FT3、FT4明显低于对照组,TSH、ApoB、hs-CRP水平明显高于对照组,差异有统计学意义(P<0.05)。重度组IGF-1、FT3、FT4明显低于轻度组,ApoB、hs-CRP、TSH水平明显高于轻度组,差异有统计学意义(P<0.05)。IGF-1与TSH为负相关,与FT3、FT4为正相关(P<0.05);ApoB、hs-CRP与TSH为正相关,与FT3、FT4为负相关(P<0.05)。结论 与单纯T2DM患者相比,T2DM合并SCH患者IGF-1、ApoB、hs-CRP表达异常,三者与患者甲状腺激素水平密切相关,可考虑作为临床评估T2DM合并SCH患者病情的参考指标。Objective To investigate the relationship between Insulin like growth factor 1(IGF-1),Apolipoprotein B(ApoB)and thyroid hormone in Type 2 diabetes mellitus(T2DM)combined with Hypothyroidism(SCH). Methods 88 cases of T2DM combined with SCH patients admitted to the Second Affiliated Hospital of Chengdu Medical College from March 2019 to March 2021 were collected(observation group),and according to the severity of SCH,they were divided into mild with 56 cases and severe with 32cases. In addition,86 T2DM patients treated in our hospital at the same period were selected as the control group. The levels of IGF-1,ApoB,h S-CRP and thyroid hormone in different populations and patients with different disease degrees were compared,and the correlation between IGF-1,ApoB,hs-CRP and thyroid hormone was analyzed by Pearson analysis. Results The levels of IGF-1,FT3 and FT4 in the observation group were significantly lower than those in the control group,while TSH,ApoB and hs-CRP levels were significantly higher than those in the control group,the differences were statistically significant(P<0.05). The levels of IGF-1,FT3 and FT4 in the severe group were significantly lower than those in the mild group,while the levels of Apo B,HS-CRP and TSH were significantly higher than those in the mild group,the differences were statistically significant(P<0.05). IGF-1 was negatively correlated with TSH,and positively correlated with FT3 and FT4(P<0.05). Apo B and Hs-CRP were positively correlated with TSH,and negatively correlated with FT3 and FT4(P<0.05). Conclusion Compared with patients with T2 DM alone,the expression of IGF-1,Apo B and Hs-CRP in patients with T2 DM combined with SCH is abnormal,and the three are closely related to the level of thyroid hormone in patients,which can be considered as a reference indicator for clinical evaluation of patients with T2 DM combined with SCH.

关 键 词：T2DM合并甲状腺功能减退症 IGF-1 APOB HS-CRP 甲状腺激素 

分 类 号：R587.2[医药卫生—内分泌] R581.2[医药卫生—内科学]