凝血酶调节蛋白的研究进展  

Research progress of thrombomodulin

作　　者：徐文波[1] 向秀华[1] 冯磊[1] 吴孟娜 XU Wenbo;XIANG Xiuhua;FENG Lei;WU Mengna(Department of Medical Laboratory,the Sixth Affiliated Hospital of Kunming Medical University,Yuxi City People's Hospital,Yuxi,Yunnan,China,653100)

机构地区：[1]玉溪市人民医院昆明医科大学第六附属医院医学检验科,云南玉溪653100

出　　处：《分子诊断与治疗杂志》2022年第7期1263-1266,共4页Journal of Molecular Diagnostics and Therapy

摘　　要：凝血酶调节蛋白(TM)是血管内皮细胞膜表面的一种蛋白聚糖,通过与凝血酶结合,可起到抗炎、抗凝血、抗血栓、抗纤溶等多种作用。当血管内皮细胞受损时,机体TM表达异常。TM被认为是判断血管内皮细胞是否正常的一个客观指标,并与恶性肿瘤、心脑血管疾病、肾脏疾病、呼吸系统疾病、血液疾病等多种疾病的发生、发展密切相关。本文将从TM的结构、功能、相关作用等方面的研究进展进行综述,以期为临床疾病的诊断和鉴别提供理论性依据。Thrombomodulin(TM)is a proteoglycan on the surface of vascular endothelial cell membrane. By combining with thrombin,TM has anti-inflammatory,anticoagulant,antithrombotic,and antifibrinolytic effects. TM expression is abnormal when vascular endothelial cells are damaged. Thus TM is considered as an objective indicator to judge whether vascular endothelial cells are normal or not,and is closely related to the occurrence and development of various diseases,such as malignant tumors,cardiovascular and cerebrovascular diseases,kidney diseases,respiratory diseases and blood diseases. This article will review the research progress on the structure,function,and related effects of TM,in order to provide theoretical basis for the diagnosis and differentiation of clinical diseases.

关 键 词：凝血酶调节蛋白 恶性肿瘤 心脑血管疾病 糖尿病肾病 

分 类 号：R341[医药卫生—基础医学]