阿魏酸钠治疗糖尿病肾病的疗效及对患者肾间质纤维化及尿微量蛋白的影响  

Effect of Sodium Ferulate on Renal Interstitial Fibrosis and Urinary Microprotein in Diabetic Nephropathy

作　　者：苗丰 罗改莹 MIAO Feng;LUO Gai-ying(Department of Pharmacy,Yulin No.2 Hospital,Yulin Shaanxi 719000)

机构地区：[1]陕西省榆林市第二医院药剂科,陕西榆林719000 [2]西安市第五医院检验科,陕西西安710082

出　　处：《医学临床研究》2022年第6期835-837,842,共4页Journal of Clinical Research

基　　金：陕西省自然科学基础研究计划项目(2019MM-585)。

摘　　要：【目的】探讨阿魏酸钠治疗糖尿病肾病(DN)的疗效及对肾间质纤维化及尿微量蛋白的影响。【方法】在两院治疗的100例DN患者,随机分为观察组和对照组,每组50例。对照组给予常规降糖、降压等基础治疗;观察组在对照组基础上给予阿魏酸钠注射液,两组均治疗2周。比较两组治疗效果,两组治疗前及治疗后1个月血管紧张素Ⅱ(AngⅡ)、结缔组织生长因子(CTGF)、Ⅳ型胶原(CⅣ)、Ⅲ型前胶原(PCⅢ)及血尿素氮(BUN)、血肌酐(SCr)、β2-微球蛋白(β2-MG)、尿微量白蛋白(UmAlb)水平,记录两组用药不良反应发生情况。【结果】观察组临床总有效率显著高于对照组(P<0.05);两组治疗后AngⅡ、CTGF、CⅣ及PCⅢ水平显著低于治疗前(P<0.05),且观察组治疗后AngⅡ、CTGF、CⅣ及PCⅢ水平显著低于对照组(P<0.05);两组治疗后SCr、BUN、β2-MG及UmAlb水平显著低于治疗前(P<0.05),观察组治疗后SCr、BUN、β2-MG及UmAlb水平显著低于对照组(P<0.05);两组用药后不良反应发生率相比较,差异无统计学意义(P>0.05)。【结论】阿魏酸钠治疗DN可有效降低患者肾间质纤维化及尿微量蛋白指标,保护肾脏功能,且无明显药物不良反应,值得临床推广。【Objective】To observe the effect of sodium ferulate on renal interstitial fibrosis and urinary microprotein in patients with diabetic nephropathy.【Methods】A total of 100 patients with diabetic nephropathy treated in the two hospitals were divided into the observation group and the control group according to random number table method,with 50 cases in each group.The control group was given basic treatment such as routine hypoglycemic and antihypertensive treatment,,While the observation group was given sodium ferulate injection on the basic treatment of the control group.Patients in both groups received treatment for 2 weeks.The therapeutic effects of the two groups were observed.Angiotensin Ⅱ(AngⅡ),connective tissue growth factor(CTGF),type Ⅳ collagen(CⅣ),type Ⅲ procollagen(PCⅢ),blood urea nitrogen(BUN),blood creatinine(SCr),β2-microglobulin(β2-MG)and urinary microalbumin(UmAlb)were measured before and 1 month after treatment.The drug adverse reactions of the two groups were counted.【Results】The total effective rate in observation group was significantly higher than that in control group(P<0.05).The levels of AngⅡ,CTGF,CⅣ and PCⅢ in the two groups after treatment were significantly lower than those before treatment(P<0.05).After treatment,the levels of AngⅡ,CTGF,CⅣ and PCⅢ in the observation group were significantly lower than those in the control group(P<0.05).The levels of SCr,BUN,β2-MG and UmAlb in both groups after treatment were significantly lower than before treatment(P<0.05).And the levels of SCr,BUN,β2-MG and UmAlb in observation group were significantly lower than those in control group after treatment(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).【Conclusion】Treatment of diabetic nephropathy with sodium ferulate can effectively reduce renal interstitial fibrosis and urinary microprotein index,and protect renal function.No obvious adverse drug reactions were seen,which is worthy of clinical promotion.

关 键 词：糖尿病肾病/药物疗法 阿魏酸/药理学 肾炎 间质性 白蛋白尿 

分 类 号：R587.24[医药卫生—内分泌]