麻杏石甘汤治疗支气管哮喘的临床疗效及对炎性因子的影响  

Clinical efficacy of Maxing Shigan Decoction in the treatment of bronchial asthma and its influence on inflammatory factors

作　　者：丁亚萍 DING Ya-ping(Rugao Boai Hospital,Rugao 226500,China)

机构地区：[1]如皋博爱医院,226500

出　　处：《中国现代药物应用》2022年第12期19-22,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探究支气管哮喘治疗中麻杏石甘汤的治疗效果及对炎性因子水平的影响。方法100例支气管哮喘患者,根据治疗方法不同分为对照组和研究组,每组50例。对照组患者行常规西药治疗,研究组患者行麻杏石甘汤治疗。比较两组患者治疗效果、哮喘控制情况及治疗前后肺功能指标[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC]、炎性因子[白细胞介素-6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)和白细胞介素-8(IL-8)]水平。结果研究组治疗总有效率为96.00%,明显高于对照组的82.00%,差异具有统计学意义(P<0.05)。治疗后,两组患者哮喘控制测试(ACT)评分高于本组治疗前,且研究组患者ACT评分(26.72±2.36)分高于对照组的(21.54±2.52)分,差异具有统计学意义(P<0.05)。治疗后,两组患者FEV1、FVC、FEV1/FVC均较本组治疗前升高,且研究组患者FEV1(2.73±0.64)L、FVC(3.78±0.77)L、FEV1/FVC(71.66±3.57)%高于对照组的(2.18±0.51)L、(3.34±0.71)L、(65.16±3.25)%,差异具有统计学意义(P<0.05)。治疗后,两组患者TNF-α、IL-6、IL-8、CRP水平均较本组治疗前降低,且研究组患者TNF-α(38.15±9.03)ng/L、IL-6(9.71±3.12)ng/L、IL-8(110.17±18.52)ng/L、CRP(5.02±1.49)mg/L低于对照组的(46.43±10.12)ng/L、(12.86±3.15)ng/L、(132.05±18.74)ng/L、(7.78±2.16)mg/L,差异具有统计学意义(P<0.05)。结论采用麻杏石甘汤治疗支气管哮喘效果显著,可有效控制哮喘程度,改善肺功能水平,降低炎性因子水平,具有良好的应用价值。Objective To investigate the effect of Maxing Shigan Decoction in the treatment of bronchial asthma and its influence on inflammatory factors.Methods A total of 100 patients with bronchial asthma were divided into control group and research group according to different treatment methods,with 50 cases in each group.Patients in the control group were treated with conventional Western medicine,and patients in the research group were treated with Maxing Shigan Decoction.Both groups were compared in terms of therapeutic effect,asthma control and pulmonary function indexes[forced expiratory volume in the 1st second(FEV1),forced vital capacity(FVC),FEV1/FVC],inflammatory factors[interleukin-6(IL-6),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interleukin-8(IL-8)]before and after treatment.Results The total effective rate of treatment in the research group was 96.00%,which was significantly higher than 82.00% in the control group,and the difference was statistically significant(P<0.05).After treatment,the asthma control test(ACT)scores of the two groups were higher than those of this group before treatment,and the ACT score(26.72±2.36)points of the research group were higher than(21.54±2.52)points of the control group.All the differences were statistically significant(P<0.05).After treatment,the FEV1,FVC,FEV1/FVC in the two groups were all increased compared with those before treatment in this group,and the FEV1(2.73±0.64)L,FVC(3.78±0.77)L,FEV1/FVC(71.66±3.57)% in the research group were higher than(2.18±0.51)L,(3.34±0.71)L,(65.16±3.25)% in the control group.All the differences were statistically significant(P<0.05).After treatment,the levels of TNF-α,IL-6,IL-8 and CRP in the two groups were lower than those before treatment in this group,and the TNF-α(38.15±9.03)ng/L,IL-6(9.71±3.12)ng/L,IL-8(110.17±18.52)ng/L,CRP(5.02±1.49)mg/L in the research group were lower than(46.43±10.12)ng/L,(12.86±3.15)ng/L,(132.05±18.74)ng/L,(7.78±2.16)mg/L in the control group.All the differences were statistic

关 键 词：麻杏石甘汤 支气管哮喘 疗效 炎性因子 影响 

分 类 号：R256.12[医药卫生—中医内科学]