疏肝健脾中药联合熊去氧胆酸胶囊治疗脾虚型妊娠期肝内胆汁淤积症患者的临床效果观察  

Clinical effect of liver-soothing and spleen-strengthening traditional Chinese medicine combined with ursodeoxycholic acid capsule on patients with spleen deficiency type of intrahepatic cholestasis of pregnancy

作　　者：谭国勋[1] 刘佩珊 梁丽笙[1] 徐烨 TAN Guo-xun;LIU Pei-shan;LIANG Li-sheng(Department of Obstetrics,Nanhai District Maternal and Child Health Hospital,Foshan 528000,China)

机构地区：[1]佛山市南海区妇幼保健院产科,528000

出　　处：《中国现代药物应用》2022年第12期23-26,共4页Chinese Journal of Modern Drug Application

基　　金：佛山市自筹经费类科技计划项目(医学类科技攻关项目)(项目编号:2020001004570)。

摘　　要：目的研究疏肝健脾中药联合熊去氧胆酸胶囊治疗脾虚型妊娠期肝内胆汁淤积症(ICP)患者的临床疗效。方法60例脾虚型ICP患者作为研究对象,根据治疗方式不同分为对照组和观察组,每组30例。对照组采用熊去氧胆酸胶囊治疗,观察组在对照组治疗基础上再增加疏肝健脾中药治疗。比较两组患者治疗前后的血清生化指标[血清总胆汁酸(TBA)、甘胆酸(CG)]以及纳少症候发生情况、治疗后住院时间。结果治疗后,观察组TBA(10.82±0.34)μmol/L、CG(5.19±0.44)mg/L均低于对照组的(24.22±1.91)μmol/L、(9.33±1.09)mg/L,差异均具有统计学意义(P<0.05)。两组治疗后纳少症候发生率均低于治疗前,且观察组纳少症候发生率10.00%低于对照组的46.67%,差异均具有统计学意义(P<0.05)。观察组治疗后住院时间(12.15±2.11)d短于对照组的(20.99±2.52)d,差异具有统计学意义(P<0.05)。结论脾虚型ICP患者接受疏肝健脾中药联合熊去氧胆酸联合治疗可有效促进患者纳少症候的改善,TBA、CG水平显著降低,住院时间显著缩短。Objective To study the clinical efficacy of liver-soothing and spleen-strengthening traditional Chinese medicine combined with ursodeoxycholic acid capsule on patients with spleen deficiency type of intrahepatic cholestasis of pregnancy(ICP).Methods A total of 60 patients with spleen deficiency type of ICP were taken as the research subjects,and were divided into control group and observation group according to different treatment methods,with 30 cases in each group.The control group was treated with ursodeoxycholic acid capsules,and the observation group was additionally treated with liver-soothing and spleen-strengthening traditional Chinese medicine on the basis of the treatment of the control group.The serum biochemical indexes[serum total bile acid(TBA),glycocholic acid(CG)]before and after treatment,the occurrence of poor appetite and digestion syndrome,and hospitalization time after treatment were compared between the two groups.Results After treatment,the TBA(10.82±0.34)μmol/L and CG(5.19±0.44)mg/L in the observation group were lower than(24.22±1.91)μmol/L and(9.33±1.09)mg/L in the control group,and the differences were statistically significant(P<0.05).The incidence of anorexia syndrome in the two groups after treatment was lower than that before treatment,and the incidence of poor appetite and digestion syndrome 10.00% in the observation group was lower than 46.67% in the control group,and the differences were statistically significant(P<0.05).The hospitalization time after treatment(12.15±2.11)d in the observation group was shorter than(20.99±2.52)d in the control group,and the difference was statistically significant(P<0.05).Conclusion For patients with spleen deficiency type of ICP,liver-soothing and spleen-strengthening traditional Chinese medicine combined with ursodeoxycholic acid can effectively promote the poor appetite and digestion syndrome,significantly lower the levels of TBA and CG,and significantly shorten the hospitalization time.

关 键 词：疏肝健脾 熊去氧胆酸 脾虚 妊娠期肝内胆汁淤积症 

分 类 号：R714.255[医药卫生—妇产科学]