二甲双胍联合胰岛素治疗妊娠期糖尿病的效果观察  

Effect observation of metformin combined with insulin on gestational diabetes mellitus

作　　者：张岩 ZHANG Yan(Department Six of Obstetrics,Shenyang Women's and Children's Hospital,Shenyang 110011,China)

机构地区：[1]沈阳市妇婴医院产六科,110011

出　　处：《中国现代药物应用》2022年第12期117-119,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探讨二甲双胍联合胰岛素治疗妊娠期糖尿病的临床效果。方法106例妊娠期糖尿病患者,随机分为长短效组和联合口服组,各53例。长短效组采用短效与长效胰岛素治疗,联合口服组在长短效组基础上增加二甲双胍治疗。比较两组治疗前后血糖水平、不良妊娠结局及不良反应发生情况。结果治疗8周后,联合口服组空腹血糖(4.72±1.42)mmol/L、餐后2 h血糖(7.15±1.63)mmol/L和糖化血红蛋白(4.39±0.79)%均低于长短效组的(5.85±1.12)mmol/L、(8.29±1.36)mmol/L和(5.79±1.13)%,差异均有统计学意义(P<0.05)。联合口服组不良妊娠结局发生率7.55%显著低于长短效组的22.64%,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论在短效与长效胰岛素治疗基础上,联合二甲双胍治疗,可有效提升妊娠期糖尿病控制效果,降低不良妊娠结局风险,安全可靠。Objective To discuss the clinical effect of metformin combined with insulin on gestational diabetes mellitus.Methods A total of 106 patients with gestational diabetes mellitus were randomly divided into long-acting and short-acting group and combined oral group,with 53 cases in each group.The long-acting and short-acting group was treated with short-acting and long-acting insulin,and the combined oral group was treated with metformin on the basis of the long-acting and short-acting group.The blood glucose levels before and after treatment,adverse pregnancy outcomes and occurrence of adverse reactions were compared between the two groups.Results After 8 weeks of treatment,the fasting blood glucose(4.72±1.42)mmol/L,2 h postprandial blood glucose(7.15±1.63)mmol/L and glycosylated hemoglobin(4.39±0.79)% in the combined oral group were lower than(5.85±1.12)mmol/L,(8.29±1.36)mmol/L and(5.79±1.13)%in the long-acting and short-acting group,and the differences were statistically significant(P<0.05).The incidence of adverse pregnancy outcomes in the combined oral group was 7.55%,which was significantly lower than 22.64% in the long-acting and short-acting group,and the difference was statistically significant(P<0.05).There was no statisticlly significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Short-acting and long-acting insulin therapy combined with metformin treatment can effectively improve the control effect of gestational diabetes mellitus,and reduce the risk of adverse pregnancy outcomes,and it is safe and reliable.

关 键 词：二甲双胍 长效胰岛素 短效胰岛素 妊娠期糖尿病 安全性 

分 类 号：R714.256[医药卫生—妇产科学]