新型吡唑酰胺类化合物的设计、合成与生物活性  

Design, synthesis and biological evalulation of novel pyrazolecarboxamides

作　　者：毛明珍[1] 张晓光[1] 张媛媛[1] 卫天琪 张选利 崔哲 张建功[1] 李玉新[2] MAO Ming-zhen;ZHANG Xiao-guang;ZHANG Yuan-yuan;WEI Tian-qi;ZHANG Xuan-li;CUI Zhe;ZHANG Jian-gong;LI Yu-xin(State Key Laboratory of Fluorine&N itrogen Chemicals,Xi'an Modem Chemistry Research Institute,Xi'an 710065,China;Research Insititutc of Elemento-organic Chemistry,State Key Laboratory of Elemento-organic Chemistry,Nankai University,Tianjin 300071,China)

机构地区：[1]西安近代化学研究所氟氮化工资源高效开发与利用国家重点实验室,西安710065 [2]南开大学元素有机化学研究所元素有机化学国家重点实验室,天津300071

出　　处：《农药》2022年第7期478-482,共5页Agrochemicals

摘　　要：[目的]寻找较高杀虫活性的吡唑酰胺类化合物并进行结构优化。[方法]设计合成一系列含有多种苯环2-位取代基结构的吡唑酰胺类化合物。[结果]合成了7个结构新颖的含有苯环2-位取代基结构的吡唑酰胺类化合物,其结构经过;H NMR和有机元素分析或高分辨质谱确证,并进行了杀虫活性测试研究。[结论]杀虫活性测试结果表明:部分目标化合物对小菜蛾和东方黏虫具有较好的杀虫活性,值得进一步研究。[Aims] This study aims to search for novel pyrazolecarboxamides with high insecticidal activity and then to carry out structural optimization. [Methods] A series of pyrazolecarboxamides containing 2-position substituents of benzene ring were designed and synthesized. [Results] 7 Novel pyrazolecarboxamides containing 2th position substituents of benzene ring were synthesized, their structures were confirmed by ~1H NMR and elemental analysis or HMRS. [Conclusions] The insecticidal activities of target compounds against oriental armyworm(Mythimna separata)and diamondback moth(Plutella xylostella) indicated that some of the compounds showed good insecticidal activities.

关 键 词：氯虫酰胺 吡唑酰胺类化合物 合成 杀虫活性 

分 类 号：TQ460.3[化学工程—制药化工]