“土当归”化学成分及药理作用研究进展  

Research progress on chemical constituents and pharmacological activities of Angelica gigas Nakai

作　　者：刘莲萱 洪霖 张会永[3] 郭丹丹 高慧媛[4] 吴威 LIU Lianxuan;HONG Lin;ZHANG Huiyong;GUO Dandan;GAO Huiyuan;WU Wei(Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications,Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China;Zhuhai College of Science and Technology,Zhuhai 519041,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China;Shenyang Pharmaceutical University,Shenyang 110016,China)

机构地区：[1]辽宁中医药大学中医脏象理论及应用国家教育部重点实验室,辽宁沈阳110847 [2]珠海科技学院,广东珠海519041 [3]辽宁中医药大学附属医院,辽宁沈阳110032 [4]沈阳药科大学,辽宁沈阳110016

出　　处：《沈阳药科大学学报》2022年第6期748-759,共12页Journal of Shenyang Pharmaceutical University

基　　金：岐黄学者-国家中医药领军人才支持计划(No.国中医药人教发[2018]12号);广东省自然科学基金项目(2021A1515011485);沈阳市中青年科技创新人才支持计划项目(RC190281)。

摘　　要：目的系统综述“土当归”(Angelica gigas Nakai,AGN)化学成分和药理作用的研究进展,为对其进一步深入研究和广泛使用奠定基础。方法查阅1959-2021年以来国内外相关文献63篇,进行分析和归纳总结。结果“土当归”作为我国朝鲜族常用草药,民间主要用于解毒和肿瘤治疗,现代研究表明其含有香豆素类、黄酮类、酚酸类、挥发油等化学成分,具有抗肿瘤、神经保护、免疫调节、抗菌、心脑血管保护等多重药理学活性。结论“土当归”具有较高的药用价值和广阔的开发前景,有待进一步深入研究。Objective To summarize the chemical constituents and pharmacological effects of Angelica gigas Nakai(AGN)systematically,to lay a foundation for its in-depth research and extensive application.Methods A total of 63 relevant literatures at home and abroad from 1959 to 2021 were reviewed,analyzed and summarized.Results As a herbal medicine commonly used by the Chinese-Korean people,AGN is mainly used for detoxification and tumor treatment.Modern research shows that it contains coumarins,flavonoids,phenolic acids,volatile oils and other chemical constituents,and has multiple pharmacological activities such as anti-tumor,neuroprotection,immunoregulation,antibacterial and cardiovascular and cerebrovascular protection.Conclusion AGN has high medicinal value and broad research prospects,which need to be further studied.

关 键 词：朝鲜当归 香豆素类 黄酮类 抗癌 神经保护 免疫调节 抗菌 

分 类 号：R28[医药卫生—中药学]