Referred Somatic Hyperalgesia Mediates Cardiac Regulation by the Activation of Sympathetic Nerves in a Rat Model of Myocardial Ischemia  

作　　者：Xiang Cui Guang Sun Honglei Cao Qun Liu Kun Liu Shuya Wang Bing Zhu Xinyan Gao 

机构地区：[1]Department of Physiology,Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences,Beijing 100700,China [2]Research Center of Traditional Chinese Medicine,The Affiliated Hospital of Changchun University of Chinese Medicine,Changchun,Jilin 130021,China [3]Department of Cardiology,Jining No.1 People’s Hospital,Jining 272100,Shandong,China [4]Department of Needling Manipulation,Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences,Beijing 100700,China

出　　处：《Neuroscience Bulletin》2022年第4期386-402,共17页神经科学通报（英文版）

基　　金：supported by the National Key R&D Program of China(2018YFC1704600);the National Natural Science Foundation of China(81674085,81904309).

摘　　要：Myocardial ischemia(MI)causes somatic referred pain and sympathetic hyperactivity,and the role of sensory inputs from referred areas in cardiac function and sympathetic hyperactivity remain unclear.Here,in a rat model,we showed that MI not only led to referred mechanical hypersensitivity on the forelimbs and upper back,but also elicited sympathetic sprouting in the skin of the referred area and C8–T6 dorsal root ganglia,and increased cardiac sympathetic tone,indicating sympathetic-sensory coupling.Moreover,intensifying referred hyperalgesic inputs with noxious mechanical,thermal,and electro-stimulation(ES)of the forearm augmented sympathetic hyperactivity and regulated cardiac function,whereas deafferentation of the left brachial plexus diminished sympathoexcitation.Intradermal injection of the α_(2) adrenoceptor(α_(2)AR)antagonist yohimbine and agonist dexmedetomidine in the forearm attenuated the cardiac adjustment by ES.Overall,these findings suggest that sensory inputs from the referred pain area contribute to cardiac functional adjustment via peripheral α_(2)AR-mediated sympathetic-sensory coupling.

关 键 词：Sympathetic-sensory coupling NEUROMODULATION Referred pain α_(2)adrenoceptor Cardioprotectio 

分 类 号：R542.2[医药卫生—心血管疾病]