Parkin Inhibits Static Mechanical Pain by Suppressing Membrane Trafficking of Mechano-transducing Ion Channel TACAN  

作　　者：Yi Lei Man-Xiu Xie Xian-Ying Cao Xi Zhang Yi-Bin Xiao Xiao-Yu Tian Yuan-Xin Zhu Xiao-Long Zhang 

机构地区：[1]College of Food Science and Engineering,Hainan University,Haikou 570228,China [2]Medical Research Center of Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510080,China [3]Department of Anesthesiology,Sun Yat-sen University Cancer Center,State Key Laboratory of Oncology in South China,Collaborative Innovation Center for Cancer Medicine,Guangzhou 510060,China [4]Hainan Senile Health Management Engineering Technology Research Center,Haikou 571126,China

出　　处：《Neuroscience Bulletin》2022年第4期429-434,共6页神经科学通报（英文版）

基　　金：supported by National Natural Science Foundation of China(82001172,82171230);Guangdong Basic and Applied Basic Research Foundation(2019A1515110014);Excellent Young Talents Project of Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences;Science and Technology Special Foundation of Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences(2020bq20).

摘　　要：Dear Editor,Clinical practice shows that harmless mechanical stimulation can cause pain in humans after inflammation or nerve injury,leading to asensation called mechanical allodynia[].Mechanicalallodyniacomesin many forms:dynamic allodynia caused by something as light as a brushstroke,static allodynia caused by stimulation by weak von Frey filaments[2],which seriously disturbs thequalityof life and working abilityofpatients.Parkin,an E3ubiquitin ligase,is linked to neurodegenerative diseases such as Parkinson's disease(PD)and Alzheimer's disease(AD)[3,4].

关 键 词：STIMULATION SENSATION PARKIN 

分 类 号：R338[医药卫生—人体生理学]