Stable isotope labeling of nanomaterials for biosafety evaluation and drug development  

作　　者：Xue-Ling Chang Lingyun Chen Boning Liu Sheng-Tao Yang Haifang Wang Aoneng Cao Chunying Chen 

机构地区：[1]CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,Institute of High Energy Physics,Chinese Academy of Sciences,Beijing 100049,China [2]Key Laboratory of Pollution Control Chemistry and Environmental Functional Materials for Qinghai-Tibet Plateau of the National Ethnic Affairs Commission,School of Chemistry and Environment,Southwest Minzu University,Chengdu 610041,China [3]Institute of Nanochemistry and Nanobiology,Shanghai University,Shanghai 200444,China [4]CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience,National Center for Nanoscience and Technology of China,and University of Chinese Academy of Sciences,Beijing 100190,China

出　　处：《Chinese Chemical Letters》2022年第7期3303-3314,共12页中国化学快报（英文版）

基　　金：financial support from the National Key Research and Development Program of China(No.2021YFA1200904);the Beijing Natural Science Foundation(No.2202065);the Fundamental Research Funds for the Central Universities,Southwest Minzu University(No.2021PTJS36);Major instrument project of National Natural Science Foundation of China(No.22027810)。

摘　　要：Quantitative information,such as environmental migration,absorption,biodistribution,biotransformation,and elimination,is fundamental and essential for the nanosafety evaluations of nanomaterials.Due to the complexity of biological and environmental systems,it is challenging to develop quantitative approaches and tools that could characterize intrinsic behaviors of nanomaterials in the organisms.The isotopic tracers are ideal candidates to tune the physical properties of nanomaterials while preserving their chemical properties.In this review article,we summarized the stable isotope labeling methods of nanomaterials for evaluating their environmental and biological effects.The skeleton labeling protocols of carbon nanomaterials and metal/metal oxide nanoparticles were introduced.The advantages and disadvantages of stable isotope labeling were discussed in comparison with other quantitative methods for nanomaterials.The quantitative information of nanomaterials in environmental and biological systems was summarized along with the biosafety data.The benefits for drug development of nanomedicine were analyzed based on the targeting effects,persistent accumulation,and safety.Finally,the challenges and future perspectives of stable isotope labeling in nanoscience and nanotechnology were discussed.

关 键 词：Stable isotope labeling Quantification Carbon nanomaterials Metal oxide nanoparticles NANOTOXICITY Biomedical effects 

分 类 号：TQ460.1[化学工程—制药化工] TB383.1[一般工业技术—材料科学与工程]