云南省德宏州新报告HIV感染者治疗前病毒载量分布研究  

Distribution of viral load before treatment in HIV cases in Dehong prefecture,Yunnan province

作　　者：张鑫 王继宝 王译葵 段星 杨锦 杨涛 杨世江 金聪[1] 叶润华 杨跃诚 Zhang Xin;Wang Jibao;Wang Yikui;Duan Xing;Yang Jin;Yang Tao;Yang Shijiang;Jin Cong;Ye Runhua;Yang Yuecheng(National Center for AIDS/STD Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China;Department of AIDS Control and Prevention,Dehong Dai and Jingpo Autonomous Prefecture Center for Disease Control and Prevention,Mangguo 678400,China)

机构地区：[1]中国疾病预防控制中心性病艾滋病预防控制中心,北京102206 [2]德宏傣族景颇族自治州疾病预防控制中心艾滋病科,芒市678400

出　　处：《中华实验和临床病毒学杂志》2022年第3期258-262,共5页Chinese Journal of Experimental and Clinical Virology

基　　金：北京市科技计划(D171100006717001)。

摘　　要：目的了解云南省德宏州2015—2017年新报告HIV感染者的病毒载量基线及人口学特征,为德宏地区HIV防治工作提供科学依据。方法收集云南省德宏州2015—2017年新报告HIV感染者的治疗前病毒载量、CD4+T细胞计数结果及人口学信息进行回顾性分析。结果2015—2017年德宏州共计新报告HIV感染者1157例,1057例进行治疗前病毒载量检测。在1057例新报告HIV感染者中,男性占64.9%(686/1057)、25~49岁占59.5%(629/1057)、已婚占51.9%(549/1057)、少数民族占51.8%(548/1057)、中学以上学历占48.2%(510/1057)、异性传播占85%(898/1057)。新报告感染者的病毒载量中位数为8200(四分位间距:1900~44000)拷贝/ml。病毒载量介于103~105拷贝/ml的感染者占比最高,为65.7%(694/1057)。55例HIV感染者病毒载量低于检测限,其中24例CD4+T细胞数≥500个/μl。结论不同HIV感染者之间病毒载量基线水平存在差异。鉴于病毒载量基线对诊疗效果的影响,有必要在治疗前进行病毒载量检测,其结果有助于制定个性化、更有效的治疗方案。Objective To determine the baseline HIV viral load and demographic characteristics of newly diagnosed HIV cases from 2015 to 2017 in Dehong prefecture and provide a scientific basis for improving HIV prevention and treatment.Methods All newly reported HIV-infected cases from 2015 to 2017 in Dehong prefecture were included in this study.Viral load,CD4+T cell counts and the demographic characteristics were collected and retrospectively analyzed.Results From 2015 to 2017,a total of 1157 newly diagnosed HIV cases were reported in Dehong prefecture,of which 1057 cases were tested for viral load;64.9%were males,59.5%aged between 25 and 49,51.9%were married,48.2%were Han ethnicity,48.2%had middle school(or beyond)training and 85%were heterosexual.The median pre-treatment viral load of newly diagnosed HIV-infected individuals was 8200(IQR:1900-44000)copies/ml.The proportion of cases with viral load between 103-105copies/ml was the highest,accounted for 65.7%(694/1057).There were 5.2%(55/1057)whose viral load was below the detecting limit and 24 had CD4+T cell counts over 500 cells/μl.Conclusions Baseline viral load levels before treatment vary among HIV-infected individuals.In view of the impact of viral load at baseline on the effectiveness of diagnosis and treatment,it is necessary to perform viral load testing before treatment,and the result can assist in the formulation of a more personalized and effective treatment regimen.

关 键 词：人类免疫缺陷病病毒 病毒载量基线 抗逆转录病毒治疗 

分 类 号：R512.91[医药卫生—内科学]