Secondary analysis of malaria rapid diagnostic tests from rounds 5–8 of WHO product testing with a focus on false-negative results  

作　　者：Biao Xu Bo Tu Fang Chu Mohamed Jalloh Jin-Song Mu Jun-Jie Zheng Wei-Wei Chen 

机构地区：[1]Chinese Military Medical Expert Group in Sierra Leone,the Fifth Medical Center of Chinese PLA General Hospital,Beijing,100039,China [2]The 34Th Military Hospital,Wilberforce Barracks,Freetown,Sierra Leone

出　　处：《Military Medical Research》2022年第3期379-381,共3页军事医学研究（英文版）

基　　金：supported by the National Grand Program on Key Infectious Disease(2018ZX10103002-001-007);the Biosafety Special Program(19SWAQ 13)。

摘　　要：Despite the widespread use of malaria rapid diagnostic test(RDT)in clinical practice,there are a lot of challenges.We conducted a secondary analysis of 129 malaria RDT data from rounds 5–8 of the World Health Organization(WHO)product testing summary and discuss the causes of false-negative(FN)results with a focus on low parasite density,improper RDT storage,operation and interpretation,and Plasmodium falciparum with a pfhrp2/3 gene deletion.The results demonstrated that the malaria RDTs currently commercially available might cause FN results in practice.

关 键 词：MALARIA Rapid diagnostic tests False-negative results WHO product testing 

分 类 号：R531.3[医药卫生—内科学]