CalliSpheres载药微球治疗难治性乳腺癌肝转移患者的短期疗效和对肿瘤标志物的影响  

Effect of CalliSpheres drug-loaded microsphere therapy on short-term efficacy and tumor markers in patients with liver metastases of refractory breast cancer

作　　者：李鑫 杨九霄 王友杰[1] 张祖建[1] 周石 LI Xin;YANG Jiuxiao;WANG Youjie;ZHANG Zhujian;ZHOU Shi(Department of Intervational Radiology,Deyang Municipal People's Hospital,Deyang 618099,Sichuan,China;Department of Intervational Radiology,the Affiliated Hospital of Guizhou Medical University,Guiyang 550004,Guizhou,China)

机构地区：[1]德阳市人民医院介入科,四川德阳618099 [2]贵州医科大学附属医院介入科,贵州贵阳550004

出　　处：《贵州医科大学学报》2022年第7期841-846,共6页Journal of Guizhou Medical University

摘　　要：目的探讨CalliSpheres载药微球经动脉导管栓塞治疗难治性乳腺癌肝转移患者的短期疗效及对肿瘤标志物的影响。方法49例难治性乳腺癌肝转移患者分为观察组(21例,应用CalliShperes载药微球行栓塞治疗)和对照组(28例,应用碘油行栓塞治疗),采用mRECIST评价两组患者术后3个月的疗效[客观缓解率(ORR)、疾病控制率(DCR)],比较两组患者治疗前后血清血管内皮生长因子(VEGF)、癌胚抗原(CEA)及肝功能等指标,观察两组患者的不良反应。结果两组难治性乳腺癌术后肝转移患者栓塞手术成功率为100%,术后3个月时观察组肿瘤的ORR和DCR高于对照组(P<0.05);两组患者术后血清中VEGF、CEA均低于治疗前,而观察组低于对照组(P<0.05);与术前比较,两组患者术后1周静脉血AST、ALT、TBIL、WBC升高,ALB降低(P<0.05);两组患者术后不良反应为栓塞后综合征,但两组比较差异无统计学意义(P>0.05)。结论C alliSpheres载药球治疗难治性乳腺癌肝转移的短期疗效确切,且安全性高。Objective To investigate the effect of CalliSpheres drug-loaded microsphere therapy on short-term efficacy and tumor markers in patients with liver metastases of refractory breast cancer(RBCLM).Methods Forty-nine patients with RBCLM were divided into an observation group(n=21,embolized with CalliShperes drug-loaded microsphere)and control group(n=28,embolized with lipiodol).Modified RECIST(mRECIST)was used to evaluate therapeutic effect(objective response rate(ORR),disease control rate(DCR))in two groups at 3 months after surgery.Serum vascular endothelial growth factor(VEGF),carcinoembryonic antigen(CEA),liver function and other indicators were compared between two groups before and after treatment.Adverse reactions of two groups were observed.Results The success rate of embolization in patients with RBCLM after surgery was 100%in two groups.ORR and DCR of the tumors in observation group were higher than those in control group at 3 months after surgery(P<0.05).Serum levels of VEGF and CEA were lower after treatment than those before treatment in two groups,while they were lower in observation group than control group(P<0.05).When compared to before treatment,the venous blood AST,ALT,TBIL and WBC in two groups were increased at 1 week after operation,while ALB was decreased(P<0.05).Postoperative adverse reaction in two groups was post-embolization syndrome,and there was no significant difference between two groups(P>0.05).Conclusion The short-term efficacy of CalliSpheres drug-loaded spheres in treating RBCLM are definite and highly safe.

关 键 词：乳腺癌 肝转移瘤 载药微球 介入治疗 肿瘤标志物 

分 类 号：R816.5[医药卫生—放射医学] R735.7[医药卫生—临床医学]