2010—2018年河北省含麻疹成分疫苗常规免疫和补充免疫疑似预防接种异常反应对比分析  

Comparative analysis on adverse event following immunization after routine immunization and supplementary immunization activities of measles-containing vaccine in Hebei Province,2010-2018

作　　者：王亚菲[1] 许晓萌 王晶辉[1] 杜慧[1] 王易寒 崔世恒 王丽娜[1] 张富斌[1] 孙丽[1] WANG Ya-fei;XU Xiao-meng;WANG Jing-hui;DU Hui;WANG Yi-han;CUI Shi-heng;WANG Li-na;ZHANG Fu-bin;SUN Li(Hebei Provincial Center for Disease Control and Prevention,Shijiazhuang,Hebei 050021,China)

机构地区：[1]河北省疾病预防控制中心,河北石家庄050021

出　　处：《实用预防医学》2022年第7期818-822,共5页Practical Preventive Medicine

基　　金：河北省卫生健康委医学科学研究课题(20180936)。

摘　　要：目的了解河北省2010—2018年含麻疹成分疫苗(measles-containing vaccine,MCV)常规免疫和补充免疫中疑似预防接种异常反应(adverse event following immunization,AEFI)监测数据的差异,为优化MCV补充免疫策略提供科学依据。方法通过中国免疫规划信息管理系统收集的AEFI个案数据、常规免疫疫苗接种数据和各市专项上报的MCV补充免疫接种数据,采用描述流行病学方法对河北省2010—2018年MCV常规免疫和补充免疫中AEFI监测特征进行统计分析。结果河北省2010—2018年MCV常规免疫和补充免疫分别共报告AEFI个案9352例和2590例。常规免疫中AEFI总报告发生率、一般反应报告发生率、异常反应报告发生率分别为47.81/10万剂、45.31/10万剂和2.32/10万剂;补充免疫的分别是64.40/10万剂、54.03/10万剂和9.08/10万剂。严重异常反应中,常规免疫的热性惊厥、血小板计数减少、急性严重过敏反应报告发生率分别为0.07/10万剂、0.16/10万剂和0.02/10万剂;补充免疫的分别是0.35/10万剂、0.07/10万剂和0.15/10万剂。结论2010—2018年河北省MCV常规免疫和补充免疫不良反应均以一般反应为主,严重异常反应罕见。河北省MCV安全性较好。Objective To understand the differences in the surveillance data regarding adverse event following immunization(AEFI)between routine immunization and supplementary immunization activities of measles-containing vaccine(MCV)in Hebei Province during 2010-2018,and to provide a scientific basis for optimizing MCV supplementary immunization strategy.Methods We collected the data about AEFI cases,routine vaccination and supplementary immunization of MCV specially-reported by each city in Henan Province during 2010-2018 through the National Immunization Program Information Management System.Descriptive epidemiological method was used to statistically analyze the characteristics of AEFI surveillance after routine immunization and supplementary immunization of MCV.Results A total of 9,352 AEFI cases after routine immunization of MCV and 2,590 AEFI cases after supplementary immunization of MCV were reported in Hebei Province from 2010 to 2018.The reported incidence rates of total AEFI,common adverse reactions and rare adverse reactions after routine immunization were 47.81/100,000 doses,45.31/100,000 doses and 2.32/100,000 doses,respectively,while the above-mentioned incidence rates after supplementary immunization were 64.40/100,000 doses,54.03/100,000 doses and 9.08/100,000 doses,respectively.Among severe adverse reactions,the reported incidence rates of febrile convulsions,thrombocytopenia and acute severe anaphylaxis after routine immunization were 0.07/100,000 doses,0.16/100,000 doses and 0.02/100,000 doses,respectively,whereas the above-mentioned incidence rates after supplementary immunization were 0.35/100,000 doses,0.07/100,000 doses and 0.15/100,000 doses,respectively.Conclusion AEFI after routine immunization and supplementary immunization of MCV in Hebei Province during 2010-2018 was mainly common vaccine reactions,and severe reactions were extremely rare.MCV in Hebei Province is safe.

关 键 词：含麻疹成分疫苗 常规免疫 补充免疫 疑似预防接种异常反应 对比分析 

分 类 号：R186[医药卫生—流行病学]