补肾疏肝养血汤联合雌孕激素周期疗法治疗肾虚肝郁型卵巢早衰临床研究  

Clinical Study on Bushen Shugan Yangxue Tang Combined with Estrogen-Progesterone Cycle Therapy for Premature Ovarian Failure of Kidney Deficiency and Liver Depression Type

作　　者：张丽霞 陈浩波 胡慧娟 王美霞 ZHANG Lixia;CHEN Haobo;HU Huijuan;WANG Meixia

机构地区：[1]温州市中西医结合医院中医妇科,浙江温州325000

出　　处：《新中医》2022年第12期135-138,共4页New Chinese Medicine

基　　金：温州市科技局计划项目(Y20170721)。

摘　　要：目的:观察补肾疏肝养血汤联合雌孕激素周期疗法治疗肾虚肝郁型卵巢早衰(POF)的临床疗效。方法:选取60例肾虚肝郁型POF患者,按简单随机化法分为对照组和观察组各30例。对照组给予雌孕激素周期疗法(戊酸雌二醇片+地屈孕酮片)治疗,观察组在对照组基础上给予补肾疏肝养血汤治疗。2组均治疗6个月。比较2组临床疗效及治疗前后中医证候积分、性激素水平和B超检查指标,记录2组不良反应。结果:观察组总有效率86.67%,高于对照组66.67%(P<0.05)。治疗后,2组中医证候积分均较治疗前降低(P<0.05),观察组中医证候积分低于对照组(P<0.05)。治疗后,2组卵泡刺激素(FSH)、黄体生成素(LH)水平均较治疗前降低(P<0.05),雌二醇(E2)水平均较治疗前升高(P<0.05);观察组FSH、LH水平均低于对照组(P<0.05),E2水平高于对照组(P<0.05)。治疗后,2组卵巢体积、子宫内膜厚度均较治疗前增大(P<0.05),窦状卵泡数均较治疗前增多(P<0.05);观察组卵巢体积、子宫内膜厚度均大于对照组(P<0.05),窦状卵泡数多于对照组(P<0.05)。治疗期间,2组均未发生严重不良反应。结论:补肾疏肝养血汤联合雌孕激素周期疗法治疗肾虚肝郁型POF疗效显著,可有效缓解患者的临床症状、调节性激素水平、改善卵巢功能,且安全性高。Objective:To observe the clinical effect of Bushen Shugan Yangxue tang combined with estrogenprogesterone cycle therapy for premature ovarian failure(POF)of kidney deficiency and liver depression type.Methods:A total of 60 cases of POF patients of kidney deficiency and liver depression type were divided into the control group and the observation group according to simple randomization method,with 30 cases in each group.The control group was given estrogen-progesterone cycle therapy with estradiol valerate tablets and dydrogesterone tablets,and the observation group was additionally treated with Bushen Shugan Yangxue tang based on the treatment of the control group.Both groups were treated for six months.Chinese medicine syndrome scores,sex hormone levels and B-ultrasound examination indexes before and after treatment as well as the clinical effects in the two groups were compared;adverse reactions in the two groups were recorded.Results:The total effective rate was 86.67%in the observation group,higher than that of 66.67%in the control group(P<0.05).After treatment,Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment(P<0.05),and the score in the observation group was lower than that in the control group(P<0.05).After treatment,the levels of follicle stimulating hormone(FSH)and luteinizing hormone(LH)in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of estradiol(E2)were increased(P<0.05);the levels of FSH and LH in the observation group were lower than those in the control group(P<0.05),and the level of E2was higher(P<0.05).After treatment,the ovarian volume and endometrial thickness in the two groups were increased when compared with those before treatment(P<0.05),and the antral follicle count was grew(P<0.05);the ovarian volume and endometrial thickness in the observation group were higher than those in the control group(P<0.05),and the antral follicle count was more(P<0.05).During treatment,no serious adverse

关 键 词：卵巢早衰 肾虚肝郁证 补肾疏肝养血汤 戊酸雌二醇片 地屈孕酮片 中医证候 性激素 卵巢功能 

分 类 号：R711.75[医药卫生—妇产科学]