益肾清热方联合妇科千金片治疗慢性盆腔炎肾虚湿热证临床研究  

Clinical Study on Yishen Qingre Prescription Combined with Fuke Qianjin Tablets for Chronic Pelvic Inflammatory Disease with Kidney Deficiency and Damp-Heat Syndrome

作　　者：王芳 吴昆仑[1] 唐苾芯[1] WANG Fang;WU Kunlun;TANG Bixin

机构地区：[1]上海市浦东新区公利医院,上海200135

出　　处：《新中医》2022年第12期139-142,共4页New Chinese Medicine

基　　金：上海市浦东新区卫生和计划生育委员会优秀青年医学人才项目(PWRd2017-5);上海市浦东新区中医妇科重点学科(PWZxk2017-03)。

摘　　要：目的:观察益肾清热方联合妇科千金片治疗慢性盆腔炎(CPID)肾虚湿热证的临床疗效。方法:选取60例CPID肾虚湿热证患者,采用随机数字表法分为对照组和治疗组,每组30例。对照组给予妇科千金片治疗,治疗组在对照组基础上给予益肾清热方治疗。2组均治疗3个月。比较2组临床疗效,以及治疗前后视觉模拟评分法(VAS)评分、中医证候积分、血清炎症因子水平。结果:治疗组总有效率93.33%,高于对照组76.67%(P<0.05)。治疗后,2组VAS评分、中医证候积分均较治疗前降低,治疗组VAS评分、中医证候积分均低于对照组,差异均有统计学意义(P<0.05)。治疗后,2组血清白细胞介素(IL)-1β、IL-2、IL-6及肿瘤坏死因子-α(TNF-α)水平均较治疗前降低,差异均有统计学意义(P<0.05);上述4项血清炎症因子水平组间比较,差异均无统计学意义(P>0.05)。结论:益肾清热方联合妇科千金片治疗CPID肾虚湿热证可提高临床疗效,有效改善患者的临床症状,减轻炎症反应。Objective:To observe the clinical effect of Yishen Qingre prescription combined with Fuke Qianjin tablets for chronic pelvic inflammatory disease(CPID)with kidney deficiency and damp-heat syndrome.Methods:A total of 60 cases of CPID patients with kidney deficiency and damp-heat syndrome were selected and divided into the control group and the treatment group according to the random number table method,with 30 cases in each group.The control group was treated with Fuke Qianjin tablets,and the treatment group was additionally treated with Yishen Qingre prescription based on the treatment of the control group.Both groups were treated for three months.The scores of Visual Analogue Scale(VAS)and Chinese medicine syndromes and the levels of inflammatory factors in serum before and after treatment as well as the clinical effects in the two groups were compared.Results:The total effective rate was 93.33%in the treatment group,higher than that of 76.67%in the control group(P<0.05).After treatment,the scores of VAS and Chinese medicine syndromes in the two groups were decreased when compared with those before treatment,and the scores of VAS and Chinese medicine syndromes in the treatment group were lower than those in the control group,differences being significant(P<0.05).After treatment,the levels of interleukin-1β(IL-1β),interleukin-2(IL-2),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in serum in the two groups were decreased when compared with those before treatment,differences being significant(P<0.05);there were no significant differences being found in the comparison of the above four levels of inflammatory factors in serum between the two groups(P>0.05).Conclusion:Yishen Qingre prescription combined with Fuke Qianjin tablets for CPID with kidney deficiency and damp-heat syndrome can improve the clinical effect,effectively improve clinical symptoms and relieve inflammatory response.

关 键 词：慢性盆腔炎 肾虚湿热证 益肾清热方 妇科千金片 视觉模拟评分法 中医证候 炎症因子 

分 类 号：R711.33[医药卫生—妇产科学]