CD4^(+)调节性T细胞:功能异质性、分群与疾病  

CD4^(+)regulatory T cell:functional heterogeneity,subsets and relevant diseases

作　　者：林瀚青 陶磊 路丽明[2] LIN Han-qing;TAO Lei;LU Li-ming(Department of Otorhinolaryngology,Eye&ENT Hospital of Fudan University,Shanghai 200031,China;Shanghai Institute of Immunology,Shanghai 200025,China)

机构地区：[1]复旦大学附属眼耳鼻喉科医院耳鼻咽喉科,上海200031 [2]上海市免疫学研究所,上海200025

出　　处：《现代免疫学》2022年第2期89-96,共8页Current Immunology

基　　金：国家自然科学基金面上项目(81671579,31370904,30972691);上海市浦江人才计划(15PJD021);上海市科学技术委员会项目(18140903800,15401900500);上海市曙光人才计划(16SG14);上海市转化医学协同创新中心合作项目(TM201522,TM201721);国家重点研发计划项目(2017YFA0104500)。

摘　　要：传统观点认为,CD4^(+)调节性T细胞(regulatory T cell,Treg)是1类能够感知免疫应答强弱并具有负向调控作用的细胞亚群,在机体免疫自稳及免疫耐受的维持中发挥重要作用。近年来新的功能学研究发现,CD4^(+)Treg在一些疾病中并不能起到抑制免疫反应的作用,反而能够促进炎症损伤或抑制组织重塑,表明CD4^(+)Treg存在功能异质性。文章将回顾相关研究,对CD4^(+)Treg异质性、分群及与相关疾病的关系展开综述。Conventionally,CD4^(+)regulatory T cell(Treg)is viewed as a subset of cells that senses the intensity of immune response and accordingly elicits negative regulatory functions.Treg is essential in the maintenance of immune homeostasis and immune tolerance in vivo.However,latest functional studies have revealed that,in some diseases,instead of suppressing the immune response,CD4^(+)Treg may promote inflammatory damage or inhibit tissue remodeling,suggesting the functional heterogeneity of CD4^(+)Treg.This review will present an overview of CD4^(+)Treg heterogeneity,functional subsets,and its relation with diseases.

关 键 词：调节性T细胞 叉头样蛋白3 功能性亚群 临床试验 

分 类 号：R392[医药卫生—免疫学]