地龙化学成分及药理活性研究进展  

Research development of Pheretima on chemical composition and pharmacological activity

作　　者：商烨 齐丽娜 金华[1] 李晋[1] 何俊[1] 常艳旭[1] SHANG Ye;QI Lina;JIN Hua;LI Jin;HE Jun;CHANG Yanxu(Tianjin State Key Laboratory of Modern Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学天津市现代中药重点实验室,天津301617

出　　处：《药物评价研究》2022年第5期989-996,共8页Drug Evaluation Research

基　　金：国家重点研发计划资助项目(2019YFC1711000)。

摘　　要：地龙是传统中药,具有清热定惊、通络、平喘等功效,临床常用于治疗高热神昏、肺热咳喘、半身不遂等。地龙所含化学成分众多,其中氨基酸类、多肽类、核苷类和有机酸等类化合物为其主要活性成分。现代药理研究表明地龙具有抗炎、抗血栓、心脏保护、抗肿瘤和改善呼吸系统功能等作用。总结了近年来国内外有关地龙化学成分、药理活性相关文献,对其研究进展进行综述,为地龙的药物开发及临床应用提供依据。Pheretima is a traditional Chinese medicine. It has the effects of clearing heat, calming convulsion, unblocking collaterals and relieving asthma. It is often used clinically for the treatment of high fever, dizziness, lung heat, cough asthma and hemiplegia.Pheretima contains many chemical components, among which amino acids, polypeptides, nucleosides and organic acids are the main ingredients. Modern pharmacological studies showed that Pheretima has anti-inflammatory, antithrombosis, cardioprotection, antitumor and respiratory system improvement effects. This article summarizes the research progress on chemical components and pharmacology of Pheretima in recent years for providing a basis for pheretima drug development and clinical application.

关 键 词：地龙 化学成分 抗血栓 心脏保护 抗肿瘤 

分 类 号：R285.5[医药卫生—中药学]