抗纤益心方联合西药对扩张型心肌病患者血清高敏C-反应蛋白、内皮素-1、B型脑钠肽前体表达的影响  

Effect of Kangxian Yixin Prescription Combined with Western Medicine on Expres⁃sions of High-Sensitivity C-Reactive Protein in Serum,Endothelin-1 and NT-ProBNP in Patients with Dilated Cardiomyopathy

作　　者：聂恒[1] 贾成军[1] 黄斌[1] 苏帆 李治兵 NIE Heng;JIA Chengjun;HUANG Bin;SU Fan;LI Zhibing

机构地区：[1]河南省中医院心病科,河南郑州450003

出　　处：《新中医》2022年第13期32-35,共4页New Chinese Medicine

基　　金：国家自然科学基金青年基金资助项目(81403330)。

摘　　要：目的:观察抗纤益心方联合西药对扩张型心肌病(DCM)患者心功能及血清相关因子水平的影响。方法:选取94例DCM患者,按随机数字表法分为对照组及观察组各47例。对照组采用常规西药治疗,观察组在对照组西药治疗基础上加用抗纤益心方,2组均治疗6个月。比较2组治疗前后心功能指标[左心室舒张末期内径(LVEDD)、左心室射血分数(LVEF)、缩短分数(FS)]及内皮素-1(ET-1)、血清高敏C-反应蛋白(hs-CRP)、B型脑钠肽前体(NT-proBNP)水平的变化。结果:治疗后,2组LVEDD指标值均较治疗前下降,LVEF、FS指标值均较治疗前升高,差异均有统计学意义(P<0.05);观察组LVEDD指标值低于对照组,LVEF、FS指标值均高于对照组,差异均有统计学意义(P<0.05)。治疗后,2组ET-1、NT-proBNP、hs-CRP水平均较治疗前下降,观察组上述3项指标值均低于对照组,差异均有统计学意义(P<0.05)。结论:抗纤益心方联合西药治疗DCM,可改善患者心功能,改善血管内皮功能,减轻机体炎症状态。Objective:To observe the effect of Kangxian Yixin prescription combined with western medicine on the levels of heart function and serum related factors in patients with dilated cardiomyopathy(DCM).Methods:A total of 94 cases of DCM patients were selected and divided into the control group and the observation group according to the random number table method,with 47 cases in each group.The control group was treated with routine western medicine,and the observation group was additionally treated with Kangxian Yixin prescription based on the treatment of the control group.Both groups were treated for six months.The changes in the heart function indexes including left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF)and fractional shortening(FS),as well as the levels of endothelin-1(ET-1),high-sensitivity C-reactive protein(hs-CRP)in serum and N-terminal probrain natriuretic peptide(NT-proBNP)before and after treatment in the two groups were compared.Results:After treatment,the LVEDD values in the two groups were decreased when compared with those before treatment,and the values of LVEF and FS were increased,differences being significant(P<0.05);LVEDD value in the observation group was lower than that in the control group,and the indexes of LVEF and FS were higher,differences being significant(P<0.05).After treatment,the levels of ET-1,NTproBNP and hs-CRP in the two groups were decreased when compared with those before treatment,and the above three levels in the observation group were lower than those in the control group,differences being significant(P<0.05).Conclusion:The therapy of Kangxian Yixin prescription combined with western medicine for DCM can improve heart function and vascular endothelial function,and relieve the inflammatory state.

关 键 词：扩张型心肌病 抗纤益心方 心功能 高敏C-反应蛋白 内皮素-1 B型脑钠肽前体 

分 类 号：R542.2[医药卫生—心血管疾病]