注射用帕瑞昔布钠与3种临床常用输液的配伍稳定性研究  

Compatible Stability of Parecoxib Sodium for Injection with Three Kinds of Commonly Used Infusion

作　　者：谢姣[1] 周素琴[2] 贾晨[2] 马旭阳 张圣苗 杨洁[2] 高建丽 王睿 赵慧[2] XIE Jiao;ZHOU Suqin;JIA Chen;MA Xuyang;ZHANG Shengmiao;YANG Jie;GAO Jianli;WANG Rui;ZHAO Hui(Dept.of Pharmacy,the Second Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710004,China;Dept.of Pharmacy,Lanzhou University Second Hospital,Lanzhou 730030,China;Dept.of Pharmacy,the First People’s Hospital of Fuyang District,Hangzhou 311400,China)

机构地区：[1]西安交通大学第二附属医院药学部,西安710004 [2]兰州大学第二医院药学部,兰州730030 [3]杭州市富阳区第一人民医院药剂科,杭州311400

出　　处：《中国医院用药评价与分析》2022年第7期777-779,783,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：国家自然科学基金资助项目(No.82003860);甘肃省青年科技基金计划项目(No.21JR7RA431);2020中医药传承平台建设项目(No.TCM-IPC-2020-06)。

摘　　要：目的:研究室温(20~25℃)下48 h内,注射用帕瑞昔布钠与3种常用输液(0.9%氯化钠注射液、5%葡萄糖注射液和葡萄糖氯化钠注射液)的配伍稳定性,为临床合理使用帕瑞昔布钠提供参考。方法:采用高效液相色谱法,检测注射用帕瑞昔布钠分别与0.9%氯化钠注射液、5%葡萄糖注射液、葡萄糖氯化钠注射液配伍后的含量变化,观察配伍后溶液的pH及外观变化。结果:注射用帕瑞昔布钠与3种注射液配伍后,在室温下放置48 h,其pH及外观未发生明显改变,含量变化<10%,说明注射用帕瑞昔布钠在上述3种输液中稳定性较好。结论:注射用帕瑞昔布钠与0.9%氯化钠注射液、5%葡萄糖注射液、葡萄糖氯化钠注射液配伍后在室温下48 h内稳定。OBJECTIVE:To investigate the compatible stability of parecoxib sodium for injection with three kinds of commonly used infusion solution(0.9%sodium chloride injection,5%glucose injection and glucose sodium chloride injection)within 48 h at room temperature(from 20℃to 25℃),so as to provide clinical reference for rational application of parecoxib sodium.METHODS:High performance liquid chromatography was used to detect the content changes of parecoxib sodium for injection compatible with 0.9%sodium chloride injection,5%glucose injection and glucose sodium chloride injection,respectively,and changes of pH and appearance of the compatible solution were observed.RESULTS:After the compatibility with three kinds of injection,the pH and appearance of parecoxib sodium for injection did not change significantly,and the change of its content was<10%after being placed at room temperature for 48 h,which indicated that the parecoxib sodium for injection had good stability in compatibility with the three kinds of infusion.CONCLUSIONS:Parecoxib sodium for injection is stable within 48 h at room temperature after compatibility with 0.9%sodium chloride injection,5%glucose injection and glucose sodium chloride injection.

关 键 词：注射用帕瑞昔布钠 配伍稳定性 高效液相色谱法 

分 类 号：R942[医药卫生—药剂学]