补肺健脾方联合氯雷他定糖浆治疗肺脾两虚型儿童变应性鼻炎的疗效观察  

Efficacy of Bufei Jianpi Recipe Combined with Loratadine Syrup in the Treatment of Allergic Rhinitis in Children with Deficiency of Lung and Spleen

作　　者：王秀敏[1] 袁硕 蒋锐 顾亦婷 WANG Xiumin;YUAN Shuo;JIANG Rui;GU Yiting(Dept.of Otolaryngology,Kunshan Hospital of Traditional Chinese Medicine,Jiangsu Kunshan 215300,China)

机构地区：[1]昆山市中医医院耳鼻喉科,江苏昆山215300

出　　处：《中国医院用药评价与分析》2022年第7期847-850,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：江苏省卫生健康委医学科研项目(No.H2019137);昆山市科技计划项目(No.KS18031)。

摘　　要：目的:探讨补肺健脾方联合氯雷他定糖浆治疗肺脾两虚型儿童变应性鼻炎的临床疗效。方法:通过随机数表法将2018年12月至2021年9月该院收治的300例肺脾两虚型变应性鼻炎儿童分为对照组与观察组(每组150例),对照组患儿给予氯雷他定糖浆治疗,观察组患儿在对照组基础上联合补肺健脾方治疗。对比两组患儿治疗前、治疗4周后的实验室检查指标[嗜酸性粒细胞百分比(EOS%)、血清免疫球蛋白E(IgE)、C反应蛋白(CRP)和降钙素原(PCT)]水平、症状计分和体征计分,临床疗效、不良反应和治疗期间药物费用。结果:观察组患儿的总有效率较对照组高[95.33%(143/150)vs.88.00%(132/150)],差异有统计学意义(P<0.05)。治疗4周后,两组患儿的EOS%、IgE、CRP和PCT水平以及各项症状计分、体征计分均较治疗前降低,且观察组患儿的EOS%、IgE、CRP和PCT水平以及各项症状计分、体征计分均低于对照组,差异均有统计学意义(P<0.05)。观察组与对照组患儿不良反应发生率比较[3.33%(5/150)vs.2.67%(4/150)],差异无统计学意义(P>0.05);观察组患儿治疗期间的平均药物费用高于对照组,差异有统计学意义(P<0.05)。结论:补肺健脾方联合氯雷他定糖浆治疗肺脾两虚型儿童变应性鼻炎的临床疗效显著,可有效调节患儿过敏体质和免疫功能,降低炎症因子水平,改善鼻炎症状和体征,安全性高,但治疗费用略高。OBJECTIVE:To probe into the clinical efficacy of Bufei Jianpi recipe combined with loratadine syrup in the treatment of allergic rhinitis in children with deficiency of lung and spleen.METHODS:Totally 300 cases of allergic rhinitis in children with deficiency of lung and spleen admitted into the hospital from Dec.2018 to Sept.2021 were extracted to be divided into the control group and the observation group via the random number table,with 150 cases in each group.The control group was treated with loratadine syrup,while the observation group received Bufei Jianpi recipe on the basis of the control group.The laboratory indicators[eosinophil percentage(EOS%),serum immunoglobulin E(IgE),C-reactive protein(CRP),procalcitonin(PCT)],symptom score,sign score before treatment and after treatment of 4 weeks,clinical efficacy,adverse drug reactions and drug cost during treatment were compared between two groups.RESULTS:The total effective rate of the observation group was higher than that of the control group[95.33%(143/150)vs.88.00%(132/150)],the difference was statistically significant(P<0.05).After treatment of 4 weeks,the levels of EOS%,IgE,CRP and PCT,the scores of various symptoms and signs of two groups were lower than those before treatment,and the levels of EOS%,IgE,CRP and PCT,and the scores of various symptoms and signs in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse drug reactions between two groups[3.33%(5/150)vs.2.67%(4/150),P>0.05].The average drug cost in the observation group was higher than that in the control group,with statistically significant difference(P<0.05).CONCLUSIONS:The clinical efficacy of Bufei Jianpi recipe combined with loratadine syrup in the treatment of allergic rhinitis in children with deficiency of lung and spleen is significant,which can effectively regulate the allergic constitution and immune function of children,reduce the level of inflammatory

关 键 词：补肺健脾方 氯雷他定糖浆 肺脾两虚型 儿童变应性鼻炎 

分 类 号：R932[医药卫生—生药学]