血清单核细胞趋化蛋白-1、β-人绒毛膜促性腺激素、孕酮及雌二醇水平预测高龄先兆流产患者保胎失败的价值探讨  

Value of serum MCP-1,β-HCG,P and E_(2) level in predicting failed fetal protection in elderly patients with threatened abortion

作　　者：胡羽晶 任叶丹 黄云柯 HU Yujing;REN Yedan;HUANG Yunke(Department of Obstetrics,Yongkang First People's Hospital,Yongkang 321300,Zhejiang,China)

机构地区：[1]永康市第一人民医院产科,浙江永康321300

出　　处：《中国性科学》2022年第7期103-107,共5页Chinese Journal of Human Sexuality

摘　　要：目的分析血清单核细胞趋化蛋白-1(MCP-1)、β-人绒毛膜促性腺激素(β-HCG)、孕酮(P)及雌二醇(E_(2))水平预测高龄先兆流产患者保胎失败的价值。方法将2018年1月至2020年7月永康市第一人民医院收治的215例高龄先兆流产患者纳入观察组,将同期孕检正常的184例高龄孕妇纳入对照组,检测两组血清MCP-1、β-HCG、P、E_(2)水平并对比。另根据观察组的保胎结局将其分为保胎成功组和保胎失败组,对比两组血清MCP-1、β-HCG、P、E_(2)水平;采用多因素Logistic回归分析血清MCP-1、β-HCG、P、E_(2)水平与观察组保胎结局的关系,并采用受试者工作特征(ROC)曲线分析以上四者联合对观察组保胎失败的预测价值。结果观察组血清MCP-1、β-HCG、P、E_(2)水平均低于对照组(P<0.05)。观察组保胎失败率为10.70%,保胎失败组血清MCP-1、β-HCG、P、E_(2)水平均低于保胎成功组(P<0.05),且均是高龄先兆流产患者保胎失败的影响因素(P<0.05);血清MCP-1、β-HCG、P、E_(2)水平联合预测高龄先兆流产患者保胎失败的灵敏度和曲线下面积(AUC)均高于单独预测(P<0.01),特异度与单独预测比较,差异无统计学意义(P>0.05)。结论高龄先兆流产患者血清MCP-1、β-HCG、P、E_(2)水平均较低,其中保胎失败患者以上指标血清水平更低,且以上指标联合对保胎失败的预测效能良好,可有效预测保胎失败。Objective To analyze the value of serum monocyte chemoattractant protein-1(MCP-1),β-human chorionic gonadotropin(β-HCG),progesterone(P)and estradiol(E_(2)) levels in predicting failed fetal protection in elderly threatened abortion patients.Methods 215 elderly pregnant women with threatened abortion treated in Yongkang First People's Hospital from January 2018 to July 2020 were selected as the observation group,and 184 elderly pregnant women with normal pregnancy examination were selected as control group.The serum MCP-1,β-HCG,P,E_(2) levels were measured and compared between the two groups.In addition,the observation group was divided into successful fetal protection group and failed fetal protection group according to the outcome of fetal protection,and the serum MCP-1,β-HCG,P,E_(2) levels of the two groups were compared.Multivariate Logistic regression analysis was used to analyze the relationships between serum MCP-1,β-HCG,P,E_(2) levels and the failure of fetal protection in the observation group,and the receiver operating characteristic(ROC)curve was used to analyze the predictive value of the combination of the above four to the failure of fetal protection in the observation group.Results The serum MCP-1,β-HCG,P,E_(2) levels in the observation group were lower than those in the control group(P<0.05).The failure rate of fetal protection in the observation group was 10.70%.The serum MCP-1,β-HCG,P,E_(2) levels in patients with failed fetal protection were lower than those in patients with successful fetal protection(P<0.05),which were the influencing factors of failed fetal protection in elderly patients with threatened abortion(P<0.05).The sensitivity and receiver operating characteristic(AUC)of serum MCP-1,β-HCG,P,E_(2) levels combined with prediction of failed fetal protection in elderly threatened abortion patients were higher than those predicted separately(P<0.01),but there was no significant difference between specificity and prediction alone(P>0.05).Conclusions The serum MCP-1,β-HCG,P,E_(2)le

关 键 词：高龄先兆流产 单核细胞趋化蛋白-1 Β-人绒毛膜促性腺激素 孕酮 雌二醇 保胎失败 

分 类 号：R714[医药卫生—妇产科学]