铋基纳米颗粒用于生物传感和生物成像的研究进展  

Research Progress on Bismuth-based Nanoparticles for Biosensing and Bioimaging

作　　者：张泽宇 胡全红[1,2] 李琳琳 ZHANG Ze-Yu;HU Quan-Hong;LI Lin-Lin(School of Chemistry and Chemical Engineering,Center on Nanoenergy Research,School of Physical Science&Technology,Guangxi University,Nanning 530004,China;Beijing Institute of Nanoenergy and Nanosystems,Chinese Academy of Sciences,Beijing 101400,China;School of Nanoscience and Technology,University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]广西大学化学化工学院,物理科学与技术学院纳米能源研究中心,南宁530004 [2]中国科学院北京纳米能源与系统研究所,北京101400 [3]中国科学院大学纳米科学与技术学院,北京100049

出　　处：《分析化学》2022年第8期1123-1130,共8页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金项目(Nos.82072065,81471784);中国科学院战略性先导科技专项项目(No.XDA16021103)资助。

摘　　要：铋(Bismuth,Bi)作为一种生物相容性好且价格低廉的金属,被用于设计合成多种具有独特结构、组成和物理化学性质的纳米材料。铋基纳米颗粒具有高X射线衰减系数和近红外吸收、出色的光热转换效率和长循环半衰期等特性,在药物递送、光热和放射治疗、多模式成像、生物传感和组织工程等领域有广泛的应用前景。本文重点综述了铋基纳米颗粒在生物传感和生物成像中的应用进展,讨论了铋基纳米材料在上述领域面临的机遇和挑战。As a biocompatible and inexpensive metal,bismuth has been used to design and synthesize various nanoparticles with unique structures,compositions and physicochemical properties.The high X-ray attenuation coefficient and near-infrared absorption,excellent photothermal conversion efficiency,and long circulation half-life of bismuth-based nanoparticles make them promising for applications in cancer drug delivery,photothermal therapy and radiotherapy,multimodal imaging,theranostics,biosensing and tissue engineering.In this review,the applications of bismuth-based nanoparticles in biosensing and bioimaging were summarized,and the opportunities and challenges faced by bismuth-based nanoparticles were also discussed.

关 键 词：铋 生物传感 生物成像 纳米颗粒 评述 

分 类 号：TB383.1[一般工业技术—材料科学与工程] Q-33[生物学]