零余子化学成分研究  

Chemical Constituents from Bulbils of Dioscorea Opposite Thunb.

作　　者：刘晏灵 郭孟焕 曹彦刚 任英杰 王梦娜 郑晓珂[1,2] 冯卫生 LIU Yan-ling;GUO Meng-huan;CAO Yan-gang;REN Ying-jie;WANG Meng-na;ZHENG Xiao-ke;FENG Wei-sheng(College of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046,China;The Engineering and Technology Center for Chinese Medicine Development of Henan Province,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学药学院,郑州450046 [2]河南省中药开发工程技术研究中心,郑州450046

出　　处：《中国药学杂志》2022年第11期890-895,共6页Chinese Pharmaceutical Journal

基　　金：国家重点研发计划资助(2017YFC1702800);河南省重大科技专项资助(171100310500)。

摘　　要：目的 研究薯蓣(Dioscorea opposite Thunb.)叶腋间珠芽(零余子)的化学成分。方法 采用硅胶、Toyopearl HW-40C、Sephadex LH-20、MCI gel CHP-20及ODS等柱色谱技术结合半制备液相色谱进行分离纯化,根据其理化性质、核磁共振(NMR)谱、质谱鉴定所得化合物结构。结果 从零余子中分离得到16个化合物,分别鉴定为吐叶醇(1)、长寿花糖苷(2)、苯乙醇-8-O-β-D-葡萄糖苷(3)、artselaeroside A(4)、benzyl-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside(5)、seguinoside E(6)、dioscorolide A(7)、芹菜素(8)、5,7-dihydroxy-2-[2-(4-hydroxyphenyl)ethyl]chromone(9)、2,7-dihydroxy-4,6-dimethoxyphenanthrene(10)、对羟基苯乙酮(11)、2-hydroxy-3,5,7-trimethoxy-9,10-dihydrophenanthrene(12)、杜鹃醇(13)、3-甲氧基-4-羟基-苯乙醇(14)、3,5-二甲氧基-4-羟基-苯乙醇(15)、4-(3,4-二羟基苯基)-2-丁酮(16)。结论 化合物2~6、9、11~16为首次从薯蓣属中分离得到,其他化合物为首次从薯蓣中分离得到。OBJECTIVE To investigate the chemical constituents from the bulbils of Dioscorea opposite Thunb. METHODS The chemical constituents were isolated and identified by various separation techniques such as silica gel, Toyopreal HW-40 C,Sephadex LH-20,MCI gel CHP-20, ODS and preparative HPLC.Their structures were elucidated by analysis of physicochemical properties and spectroscopic evidence. RESULTS Sixteen compounds were isolated and identified as vomifoliol(1), roseoside(2),phenethyl-8-O-β-D-glucopyranoside(3), artselaeroside A(4),benzyl-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside(5), seguinoside E(6),dioscorolide A(7),apigenin(8),5,7-dihydroxy-2-[2-(4-hydroxyphenyl)ethyl]chromone(9), 2,7-dihydroxy-4,6-dimethoxyphenanthrene(10),4-hydroxyacetophenone(11),2-hydroxy-3,5,7-trimethoxy-9,10-dihydrophenanthrene(12), rhododendrol(13), 3-methoxy-4-hydroxyphenethyl alcohol(14), 3,5-dimethoxy-4-hydroxyphenethyl alcohol(15), and 4-(3,4-dihydroxyphenyl)-2-butanone(16). CONCLUSION Compounds 2-6, 9 and 11-16 are isolated from genus Dioscorea for the first time, and the other compounds are isolated from this plant for the first time.

关 键 词：薯蓣属 零余子 吐叶醇 苯乙醇-8-O-β-D-葡萄糖苷 2 7-dihydroxy-4 6-dimethoxyphenanthrene 杜鹃醇 

分 类 号：R932[医药卫生—生药学]